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《Acupuncture Research》 2002-03
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Effects of Electroacupuncture on Plasma and Gastric Mucosal Levels of ET in Dogs

SUN Dayong, HUANG Yuxin 1, GAO Wei 1, CHU Zihong 1, WANG Qingli 1 (General Hospital of Guangzhou Military Commond, Guangdong Province, 510010; 1Tangdu Hospital of the 4th Military Medical University,Xi'an, 710038)  
Objective: To investigate the regulation action of electroacupuncture(EA)on gastric mucosal blood flow (GMBF) and its relation to the contents of plasma and gastric mucosal ET in dogs. Methods: Twenty mongrel dogs (body weight 15~20 kg) anesthetized with pentobarbital (1 mg/kg) were randomly and equally divided into control group,non-acupoint group,"Shangjuxu" group and "Zusanli" group. "Shangjuxu"(ST 37), "Zusanli"(ST 36) and non-acupoint (the midpoint between the small head of the fibula and the external malleolus, 1 cm to the lateral side of the fibula) were punctured and stimulated with an EA therapeutic apparatus (50 Hz, intermittent waves, 20 V) for 30 min. GMBF (gastric body) was measured by using a laser doppler flowmeter(LDF),and plasma ET contents were detected with radioimmunoassay method. Results: In "Zusanli" group,30 min after EA stimulation and cease of EA, GMBF increased significantly (P0.05, 0.01); while no significant changes were found after EA in "Shangjuxu", non-acupoint and control groups. Simultaneously, 30 min after cease of EA, marked decrease was observed in plasma ET content (P0.01) and gastric mucosa ET content (P0.01) in both "Zusnanli" and "Shangjuxu" groups, whereas no significant changes were observed in control and non-acupoint groups in plasma and gastric mucosal tissue. Conclusion: EA at "Zusanli" (ST 36) can evidently make GMBF increase, suggesting a protective effect of EA on gastric mucous. This effect is probably related to EA-induced changes of plasma and gastric mucosa brain-gut peptide and the effect of EA of different meridian acupoints is of a certain specificity.
【Fund】: 国家自然科学基金资助项目 (NO .39970 888)
【CateGory Index】: R245.97
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