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《Acupuncture Research》 2011-01
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Effect of Moderate Acupuncture-stimulation of "Taichong" (LR3) on Blood Pressure and Plasma Endothelin-1 Levels in Spontaneous Hypertension Rats

WANG Jia-you,TANG Chun-zhi1,HE Zhen-quan,ZHANG Jin,HAO Mu-feng,MA Chun-mei,YANG Zhong-hua,LAI Xin-sheng1(Department of Human Anatomy,School of Basic Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou,510006,China;1College of Acu-moxibustion and Massage,Guangzhou University of Chinese Medicine,Guangzhou 510405)  
Objective To observe the effect of different strength of acupuncture stimulation on blood pressure and plasma endothelin(E)-1 in spontaneous hypertension rats(SHR),so as to seek a better acupuncture parameter for clinical treatment of hypertension.Methods Twenty-eight 9-week-old SHRs were randomized into mild-stimulation group,moderate-stimulation group,strong-stimulation group and model group(n=7 in each group).Seven normotensive SD rats served as a normal control group.Acupuncture stimulation with mild,moderate and strong stimulation was applied to bilateral "Taichong"(LR3) for 5 min,once daily for 7 days.Blood pressure(BP) was determined by using a non-invasive BP-6 detection system.Plasma ET-1 was assayed by radioimmunoassay.Results Compared with the model group,the systolic pressure of the moderate-stimulation group on the 6th and 7th day was decreased significantly after acupuncture of "Taichong"(LR 3)(P0.01),being significantly lower than that of the mild-and strong-stimulation groups(P0.01).In comparison with the normal control group,plasma ET-1 level in the model group was increased significantly(P0.01),while compared with the model group,only that in the moderate-stimulation group was down-regulated considerably(P0.01).No significant differences were found between the mild-stimulation and model groups,between the strong-stimulation and model groups,and between the mild-stimulation and strong-stimulation groups in plasma ET-1 level(P0.05).Conclusion Moderate-stimulation of "Taichong"(LR3) can lower blood pressure and plasma EA-1 level in spontaneous hypertension rats.The reduced level of plasma ET-1 may be one of its mechanisms underlying improving hypertension.
【Fund】: 国家重点基础研究发展计划(“973”计划)课题“穴位效应规律的研究”子课题(No.2005CB523308)
【CateGory Index】: R245.311
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