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《Current Advances In Obstetrics and Gynecology》 2003-04
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Relationship between the p53,p21~(CIP1),p185 protein expression and malignant transformation in hydatidiform mole

Chi Jinghua,Ji Xiangrui.Department of Pathology,Medical College of Qingdao University,Qingdao 266021  
Objective:To explore the relationship between p53,p21 CIP1 ,p185 protein expression and malignant transformation in hydatidiform mole (HM) and the correlative clinic features in malignant transformation of HM.Method:Immunohistochemistry was used to detect expression of p53,p21 CIP1 ,p185 protein in HM,malignant mole (MM) and choriocarcinoma (CC);and the clinic data were analyzed retrospectively.Results:The positive rate of p53,p21 CIP1 and p185 protein expression in HM group was 35%(35/100),71%(71/100) and 36%(36/100),respectively;comparing with malignant group,they were significantly decreased(P0.05).Expression of p53,p21 CIP1 and p185 protein showed no significant difference (P0.05) between complete and partial HM,and between malignant transformed and non malignant transformed cases of complete HM,while p21 CIP1 expression had decreasing trend in malignant transformed group.Conclusion:There may be no obvious relationship between the change of p53, p21 CIP1 ,and p185 protein expression and malignant transformation of HM,while they can appear in malignant trophoblastic tumors as late phenomenons; and the probability of malignant transformation of HM may increase when p21 CIP1 protein expression is decreasing.
【CateGory Index】: R737.33
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