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《Modern Jorunal of Integrated Traditional Chinese and Western Medicine》 2003-16
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Effect of diet on insulin resistance and hepatic glycogen synthetase mRNA expression in rat model of non-insulin dependant diabetes mellitus

WANG De feng 1, SONG Guang Yao 2, SUN Li 1, ZHENG Gui min 2, WANG Zhi hua 2, ZHANG Wen jie 2, ZHANG Yong mei 2 (1. Affiliated Hospital of Handan High Medical Assistants School, Handan 056029, Hebei, China; 2. People's Hospital of Hebei, Shijiazhuang 050051, Hebei, China)  
Objective It is to investigate the effect of diet to insulin resistance (IR) and hepatic glycogen synthetase mRNA expression. Methods The rats were respectively fed with high sucrose, high fat and high sucrose high fat diets for four weeks. Then they were induced to non insulin dependant diabetes mellitus (NIDDM) models by injected with low dose of STZ. IR was evaluated with insulin sensitive index (ISI). The level of hepatic glycogen synthetase mRNA were detected with RT PCR. Results ISI in each experiment group was decreased. Compared with that of control group, there was significant difference ( P 0.05). The level of hepatic glycogen synthetase mRNA expression in each experiment group was decreased and significantly lower than that of control group ( P 0.05). Conclusion High sucrose, high fat and high sucrose high fat diets can induce IS and affect the expression of hepatic glycogen synthetase mRNA of NIDDM.
【CateGory Index】: R587.1
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