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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2007-28
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Study on the anti-aging function of Gynostemma pentaphyllum Makino on sub-aging rats

YAO Dan-dan,HUANG Shan-hua(Conghua College of Guangzhou Medical College,Conghua 510925,Guangdong,China)  
Objective It is to explore the effects of Gynostemma pentaphyllum Makino on sub-acute aging rats and its mechanisms.Methods 30 SD rats were randomly divideded into three groups: normal group,aging model group and Gynostemma pentaphyllum Makino group.Rats in all groups except normal group were given D-galactose by hypodermic injection to make the sub-acute aging model.The activities of SOD,MDA,GSH-Px in serum were measured by spectrophotometer.The index of thymus and spleen were also be observed.Results In the sub-acutely aging model group,the contents of SOD,GSH-Px were lower and that of MDA was higher than those in normal group(P0.01).In Gynostemma pentaphyllum Makino group,the activity of SOD,GSH-Px significantly increased,the content of MDA decreased(P0.01),and the index of thymus and spleen increased significantly compared with the model group,(P0.01).Conclusion Gynostemma pentaphyllum can improve immunity function,increase the activities of anti-oxidation enzymes,so to display its anti-aging function.
【CateGory Index】: R285.5
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