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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2008-34
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Effects of Rhubarb on respiratory function in patients with mechanical ventilation

Li Shuqing,Xu Fennian,Sun Simei,Chen Yan (The Traditional Chinese Medicine Hospital of Taizhou,Taizhou 225300,Jangsu, China)  
Objective It is to study the effect of Rhubarb on respiratory function in patients with mechanical ventilation.Methods Eighty-four patients with respiratory failure were randomly divided into two groups: the control group(treated with mechanical ventilation and normal western medicine) and the treatment group(treated with Rhubarb as well as mechanical ventilation and western medicine).The APACHEⅡscores,pH,oxygenation index,p(CO2),airway resistance,pulmonary compliance,lactic acid in all the patients were observed before and 24,48,72 and 96 hours after treatment.The average off-line time,ventilation acquired pneumonia and MODS incidence rate were observed after treatment in both groups.Results The oxygenation index,p(CO2),pulmonary compliance were markedly improved 24 hours after the treatment in two groups(P0.05).The pH,oxygenation index, lactic acid in treatment group were better than that in control group at 24 hours.The APACHEⅡ scores,pH,oxygenation index were better than that in control group(P0.05) and the pulmonary compliance,airway resistance in treatment group were markedly improved than that in control group(P0.01) at 48 hours.All indexes in treatment group kept stable at 72,96 hours.The lactic acid was obviously advanced and the pulmonary compliance was markedly decreased in control group at 72 hours than that at 48 hours(P0.05).There were significances in the average off-line time,VAP,MODS incidence rate between both groups(P0.05).Conclusion Rhubarb can improve tissue hypoxia and respiratory function of patients with mechanical ventilation by direct lung protection,and can decurtate the average off-line time,decrease incidences of depression VAP and MODS.
【CateGory Index】: R259
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