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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2009-15
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Study on screening and mechanism of action of Chinese medicine formulas on early diabetic

Cui Jun,Wang Youqun,Chang Feifei(Pharmacology Institute of China Pharmaceutical Unversity,Nanjing 210009,Jiangsu,China)  
Objective It is to screen Chinese medicine formulas and approach the mechanism of action by observing the therapeutic effects in early diabetic mice.Methods DM models were established by STZ in ICR mice,diabetic mice were divided into several groups.The amount of food-intake,water-intake was recorded, and the effects of Chinese medicine formulas on oral glucose tolerance,blood glucose(BG) changes in 24 h,and the content of NO and MDA in serum/kidney were determined.Results ①Compared with the group DM,groups formula-Ⅰ and formula-Ⅲ and formula-Ⅴ could decrease water consume apparently,and group formula-Ⅴ could also decrease food-intake and inhibit kidney hypertrophy.②Compared with the group DM,groups formula-Ⅳ and formula-Ⅴcould apparently decrease BG after fasting 3 hours,and group formula-Ⅴ decreased 1h and 2h BG and group formula-Ⅳ decreased 2h BG after glucose load significantly.And each Chinese medicine formula could keep lower BG level in 8h of 24h BG determination after 1 week drug administration.③Compared with the group DM,both group formula-Ⅰ and group formulaⅤ decreased the content of NO and MDA in serum and kidney significantly.The content of serum MDA was decreased significantly in both groups formula-Ⅱ,formula-Ⅲ and formula-Ⅳ,groups formula-Ⅲ and formula-Ⅳ can decrease the content of NO in kidney significantly.Conclusion Each Chinese medicine formula has certain antidiabetic effects,and formula-V was superior,which decreased water and food consume,improved oral glucose tolerance,inhibitted kidney hypertrophy and depressed the content of NO and MDA in serum and kidney.It could extenuate oxidative damage and inhibit lipid peroxidation because of high glucose and accentuation of oxidative stress.
【CateGory Index】: R285
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Wang Xibiao1,Du Wendong2,Yan Shihai3(1.The Central Health Center of Shangche,Guanyun 222202,Jiangsu,China; 2.Nanjing Traditional Chinese Medical University,Nanjing 210029,Jiangsu,China;3.The Traditional Chinese Medical Hospital of Jiangsu Province,Nanjing 210029,Jiangsu,China);Experiment study of the effect of Yiqi Yangyin Huoxue prescription on blood sugar[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2008-16
2 MAO Xian-qing,OUYANG Jing-ping,WU Ke,et al.Medical School of Wuhan University,Hubei Allergic & Immune Diseases Related Lab,Wuhan 430079,China;Ameliorative effect of astragalus polysaccharide (APS) on the hepatic steatosis in diabetic KKAy mice[J];Chinese Journal of Diabetes;2008-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Yan1, Ding Hong2, Xiao Geng- Fu1 1.College of Life Sciences, Wuhan University, Wuhan,Hubei,430072, P.R.China 2.College of Pharmacy, Wuhan University, Wuhan,Hubei,430072, P.R.China;Research Advances on Tumor Therapy via Nitric Oxide[J];Chinese Journal of Cancer;2004-04
2 LIU Hong-bai~(1,2), LU Tong-yan~(2), ZHANG Chun-yan~(3), SUN Da-jiang~(2),BAI Xiu-juan~1 (1.Northeast Agriculture University,Harbin 150030,China;2.Heilongjiang River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Harbin 150070,China;3.Heilongjiang Traditional Chinese Medical University,Harbin 150030,China);Effects of the aqueous extract of astragalus root Astragalus membranaceus on immunity and antioxidation in Amur sturgeon (Acipenser schrencki Brandt)[J];Journal of Dalian Fisheries University;2006-03
3 Zhou Libin, Yang Ying, Shang Wenbin, et al. Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai (200025);Berberine Improves Insulin Resistance Induced by High Fat Diet in Rats[J];Journal of Radioimmunology;2005-03
4 Wang Xiaoguang, Li Haijun (Department of TCM, Nanfang Hospital, the First Military Medical University, Guangzhou, 510515);Effects of Bupishenhuoxue Therapy on the mRNA Expression of Advanced Glycation End Products Receptors in the Renal Cortex in the Diabetic Rat[J];Journal of Beijing University of Traditional Chinese Medicine;2004-02
5 ZHANG Ru-feng(Central Hospital of Aviation Industry,Beijing 100012);Influence of Radix Astragali seu Hedysari on expression and activity of MMP-9 of myocardium in rats with type 2 diabetes[J];Journal of Beijing University of Traditional Chinese Medicine;2008-12
6 WANG Hui 1,LIANG Xiao ping 1,YU Xiao ming 2,ZUO Yi 1 (1 Dalian Harbor Hospital,Dalian 116015,Liaoning,China;2 Dalian Medical University,Dalian 116001,Liaoning,China);Observation on Intervention of Liuwei Dihuang Pill on IGT[J];Liaoning Journal of Traditional Chinese Medicine;2002-12
7 Huang Xia,Liu Huixia,Yuan Xiaohan Henan Province Chinese Medicine Research Institute,Zhengzhou,Henan,China 450004;The Exprimental Study Advancement of Diabetes Mellitus and Complication Treated with Chinese Medicine[J];China Journal of Chinese Medicine;2010-03
8 CHEN Zhennian,WEI Yirong. Department of Traditional Chinese Medicine,People`s Hospital of Heng County,Guangxi Zhuang Autonomous Region,Heng County 530300;Therapeutic effect of Manna drink on type Ⅱdiabetes[J];Hebei Journal of Traditional Chinese Medicine;2010-11
9 LIU Shu-ling,YANG Xiu-fen,GUO Jing-jing,WANG Nai-ping(Department of Pharmacology,Faculty of Pharmacyology,Guangxi Traditional Chinese Medical University,Nanning 530001,China);Studies on Hypoglycemic Action of Breviscapine in Adrenaline-induced Model Mice[J];Lishizhen Medicine and Materia Medica Research;2008-05
10 Xu Liangyin1,Zheng Zhen1,Cheng Yifu2(1.De'an Hospital,Changzhou 213003,Jiangsu,China;2.Wannan Medical College,Wuhu 241001,Anhui,China);Effect of strengthening spleen method on blood glucose level and its circadian rhythm in rats with experimental diabetes mellitus[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2008-28
China Proceedings of conference Full-text Database 3 Hits
1 Mu Chang-zheng,XieLing,MengLi (Department of Histology and Enbryology, Jinzhou Medical College, Jinzhou, 121000);The Expression of Inducible Nitric Oxide Synthase In Renal Glomerulus of Early Diabetic Rats[A];[C];2006
2 Liu Hongbai Zhang Ying (Heilongjiang River Fishery Research Institute,Chinese Academy of Fishery Sciences,Harbin 150070,China);Effects of five kinds of Chinese herbal medicine on nitric oxide concentration in serum of common carp and their remission of nitric oxide toxicity of anthon[A];[C];2003
3 WU Yiling~* LI Yanning QI Jinsheng ~*Yiling Medical Research Institution of Hebei,Shijiazhuang 050035,China;Effect of Tongxinluo on 7 genes expression profile associated with vascular endothelium injure of rats with deficiency of vital energy or qi stagnation[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Yuanjing,Shen Guoming,Wang qinmao (Department of Combination of Chinese and Western Medicin, Anhui College of TCM,Hefei 230038,China);THE PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ACUTE CEREBRAL ISCHEMIA REPERFUSION INJURY IN RATS[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-01
2 Li Feng,Zhang Xiaoming,Zhang Yun,Ye Chuanhui,Cheng Qingli (Department of TCM,Xijing Hospital,Fourth Military Medicial University,PLA,Xi’an 710032,China);EFFECT OF SHENKANG INJECTION ON LEVEL OF ET 1 AND NO SECRETION IN CULTURED GLOMERULAR MESANGIAL CELL[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-02
3 SONG Xiao ge,TANG Zhao liang,ZHU Qing feng,ZHANG Fu qing CHENG Quan zhu,HOU Zheng ming,XU Guan sun (Institute of Acupuncture and Moxibustion,Anhui College of TCM,Anhui Hefei 230038,China);EFFECT OF ACUPUNCTURE ON NITRIC OXIDE IN RATS WITH MORPHINE ABSTINENCE SYNDROME[J];Journal of Anhui Traditional Chinese Medical College;2001-06
4 Yang Tao,et al Department of Biochemistry;STUDIES ON THE PREVENTION AND TREATMENT OF GALACTOSE CATARACTS IN RATS WITH CHINESE MEDICINAL HERBS[J];;1991-02
5 SUN Jun, LI Jing-Feng, YAO Xiu-Juan, ZHAO De-Hua Department of Pharmacology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033, China;Anisodamine acts on blood pressure and NO synthesis in endotoxic shock rabbits[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-07
6 YANG Wen-Qing1, WANG Si-Wang2, XIE Yan-Hua2, WANG Jun-Qing1 1Department of Rehabilitation, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China, 2Pharmaceutical Institute, Fourth Military Medical University, Xi'an 710033;Extract from hirudo protects ischemic brain tissues[J];Journal of The Fourth Military Medical University;2001-02
7 Dong Jixing,∥Department of surgery,242 Hospital of Haerbin,(150066). Wang Chunxi,∥Department of the vascular sugery, The Ferst Affilialed. Hospital of China Medical University, Shenyang (110001).;The prophylatic study of atherosclerosis obliterans with integrated Chinese and western medicine[J];AEROSPACE MEDICINE;2000-02
8 You Zhaoling,Fu Lingmei,Lei Lei,et al (Hunan College of Traditional Chinese Medicine,Changsha Hunan 410007)[BHDWG3mm,WK40W];Experimental Research on the Effects of Gonghuanzhixue Pian on the Content of NO and Activity of NOS in Uterine Tissue of Rabbits Wearing Cu-IUD[J];Journal of Hunan College of Traditional Chinese Medicine;2001-04
9 Tan Qian,Wang Pingbao (Xiangya Hospital,Hunan Medical University,Changsha 410008);PROTECTION OF SANZIJIAMING DECOCTION TO RABBIT RETINA DAMAGED BY ACUTE GLAUCOMA[J];JOURNAL OF HUNAN COLLEGE OF TRADITIONAL CHINESE MEDICINE;1999-02
10 Tang Chaoke, Sun Ming, Wen Gebo, Hu Bi, Liao Duanfang (Department of Diagnostics of Hengyang Medical College, Hengyang, 421001);Effect of Gypenosides on Mean Arterial Pressure and Nitric Oxide Levels in Rabbits with Endotosin Induced Shock[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1999-04
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