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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2009-15
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Study on screening and mechanism of action of Chinese medicine formulas on early diabetic

Cui Jun,Wang Youqun,Chang Feifei(Pharmacology Institute of China Pharmaceutical Unversity,Nanjing 210009,Jiangsu,China)  
Objective It is to screen Chinese medicine formulas and approach the mechanism of action by observing the therapeutic effects in early diabetic mice.Methods DM models were established by STZ in ICR mice,diabetic mice were divided into several groups.The amount of food-intake,water-intake was recorded, and the effects of Chinese medicine formulas on oral glucose tolerance,blood glucose(BG) changes in 24 h,and the content of NO and MDA in serum/kidney were determined.Results ①Compared with the group DM,groups formula-Ⅰ and formula-Ⅲ and formula-Ⅴ could decrease water consume apparently,and group formula-Ⅴ could also decrease food-intake and inhibit kidney hypertrophy.②Compared with the group DM,groups formula-Ⅳ and formula-Ⅴcould apparently decrease BG after fasting 3 hours,and group formula-Ⅴ decreased 1h and 2h BG and group formula-Ⅳ decreased 2h BG after glucose load significantly.And each Chinese medicine formula could keep lower BG level in 8h of 24h BG determination after 1 week drug administration.③Compared with the group DM,both group formula-Ⅰ and group formulaⅤ decreased the content of NO and MDA in serum and kidney significantly.The content of serum MDA was decreased significantly in both groups formula-Ⅱ,formula-Ⅲ and formula-Ⅳ,groups formula-Ⅲ and formula-Ⅳ can decrease the content of NO in kidney significantly.Conclusion Each Chinese medicine formula has certain antidiabetic effects,and formula-V was superior,which decreased water and food consume,improved oral glucose tolerance,inhibitted kidney hypertrophy and depressed the content of NO and MDA in serum and kidney.It could extenuate oxidative damage and inhibit lipid peroxidation because of high glucose and accentuation of oxidative stress.
【CateGory Index】: R285
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