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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2011-15
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Protective effect of modified Huangqi Jianzhong decoction on gastric mucosa in rats with gastric ulcers induced by acetic acid

Fan Tuoying1,Zhou Hu2,Fan Qun3(1.The 94th Hospital of PLA,Nanchang 330002,Jiangxi,China;2.Donghu Hospital of Shenzhen,Shenzhen 518020,Guangdong,China)  
Objective It is to approach the protective mechanisms of modified Huangqi Jianzhong decoction on gastric mucosa in rats with gastric ulcers.Methods 60 Wistar rats were randomly divided into normal control group,model group,high does decoction group(20 g/kg),middle dose decoction group(10 g/kg),low dose decoction group(5 g/kg) and colloidal bismuth pectin group.There were 10 cases in each group.The model of chronic gastric ulcer was induced with 100% acetic acid.after treated with corresponding herbs for 16 days,the pathological of gastric mucosa,the blood prostaglandin(6-K-PGF1α),gastric juice epidermal growth factor(EGF),the stomach of nitric oxide(NO),blood super oxide dismutase(SOD) were observed.Results Modified Huangqi Jianzhong decoction promoted the rehabilitation of mucosa with gastric ulcer,and raised the levels of plasma prostaglandins,EGF in gastric juice,NO in gastric tissue and SOD in plasma.Conclusion Modified Huangqi Jianzhong decoction shows a protective effect on gastric mucosa in rats with gastric acid.
【CateGory Index】: R285.5
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