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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2013-23
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Study on shikonin in proliferation of human endometrial cancer Ishikawa cell

Yang Jingzhe,Zhang Lingxiao,Xing Yongjing,An Song,Shen Hua(The TCM Hospital of Wangdu,Wangdu 072450,Hebei,China)  
Objective It is to observe the effects of shikonnin-induced human endometrial cancer apoptosis in vitro,and approach its probable mechanisms involved,also provide proof for the clinical application.Methods The inhibition in different medicines on proliferation of Ishikawa cells was detected by MTT method;the influence of shikonin on cell cycle and apoptosis rate of endometrial cancer Ishikawa cell was observed by flow cytometry;the protein expression of Bax and Bcl-2 of Ishikawa cells in endometrial carcinoma was detected by RT-PCR method.Results The proliferation of Ishikawa cells was inhibited by shikonin,and showed obvious dose-effect relationship and time dependence.Shikonin mainly arrested cells in G1 phase,and the same time point of shikonin induce apoptosis of Ishikawa cells in a concentration dependent manner.The mechanism of shikonin induced apoptosis in endometrial carcinoma Ishikawa cells was correlated to the protein expression of Bax and BCL 2,by promoting the down-regulation of BCL-2 expression in endometrial cancer cells by inducing apoptosis and Bax expression(P 0.05).Conclusion Shikonin is effective for inhibiting the growth of endometrial Aden carcinoma Ishikawa cell and in a dose and time-dependent manner.The mechanism of promoting apoptosis and blocking cell cycle in G1 period may be related to the inhibition of protein expression of Bax and Bcl-2.
【CateGory Index】: R737.33
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