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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2014-21
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Effect of entecavir combined with Diwu Yanggan anagraph in treatment of hepatitis B virus associated nephritis and its influence on IL-2 and IFN-γ

Luo Junhua;Wang Linqun;Cao Qiushi;Wuhan General Hospital of Guangzhou Military Command of PLA;Hubei University of TCM;  
Objective It is to observe the effect of entecavir combined with Diwu Yanggan anagraph(DWYGA) in treatment of hepatitis B virus associated nephritis(HBV-GN) and its influence on IL-2 and IFN-γ.Methods 21 patients with HBV-GN were received entecavir combined with DWYGA for at least 36 weeks.The changes of clinical symptom and signs,liver and kidney function,24hUAlb,HBV DNA,IL-2 and IFN-γ were observed.Results Compared with pre-therapy,the clinical symptom and signs,liver and kidney function of patients with HBV-GN were markedly improved(P 0.01).The total effective rate was 86%,HBVDNA negative rate was 81%.The levels of IL-2 and IFN-γ were markedly heightened than pre-therapy(P 0.01).Conclusion The combined therapy with entecavir and DWYGA is effective for HBV-GN.The mechanism may be relevant to efficient anti-virus,regulate the body's immune function,and reduce the damage on kidney and liver.
【Fund】: 国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2012052)
【CateGory Index】: R692.3
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