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《Modern Journal of Integrated Traditional Chinese and Western Medicine》 2017-34
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Effects of fenofibrate combined with Shenfu injection on contrast-induced acute kidney injury in hyperuricemia coronary heart disease patients after percutaneous coronary intervention

SU Qichun;XIU Jiancheng;Nanfang Hospital of Nanfang Medical University;  
Objective It is to observe the effects of fenofibrate combined with Shenfu injection on contrast-induced acute kidney injury( CI-AKI) in hyperuricemia coronary heart disease patients after percutaneous coronary intervention( PCI),and to explore its mechanism. Methods 164 patients with hyperuricemia coronary heart disease were randomly divided into control group and observation group,84 cases in each group. Both groups received routine use of hypoglycemic,anticoagulant and lipid-lowering symptomatic treatment and postoperatively hydration therapy,the PCI was carried out by the same doctors. The observation group was treated with fenofibrate tablets and Shenfu injection from one week before treatment to 3 days after treatment. The levels of neutrophil gelatinase-associated lipocalin( NGAL),serum creatinine( SCr),urea nitrogen( BUN),blood uric acid( SUA),serum malondialdehyde( MDA),superoxide dismutase( SOD),C reactive protein( CRP),IL-6 were determined before PCI( t_0),in 6 h( t_1),24 h( t_2),48 h( t_3) after PCI,estimated glomerular filtration rate( eGFR) was evaluated in both groups. The occurrence of CI-AKI in the period of t_0—t_1,t_1—t_2 and t_2—t_3 in both groups were calculated.Results The levels of NGAL and CRP at t_1,t_2 and t_3 were significantly higher than that at t_0 in both groups( P 0. 05),and the increase of observation group was significantly lower than that in the control group( P 0. 05). The levels of SCr,SOD,IL-6 and BUN at t_2 and t_3 after surgery were significantly increased while that of eGFR and SUA was significantly decreased at these time point in the control group( P 0. 05),but the levels of SCr,IL-6 and BUN at t_2 and t_3 were significantly lower while that of eGFR was higher in the observation group than those in the control group( P 0. 05),the levels of SUA were obviously lower while that of SOD was higher at t_1,t_2,t_3 than those at t_0 and in the control group( P 0. 05). The levels of MDA at t_2 and t_3 were significantly lower that those at t_0 in both groups( P 0. 05),but the decrease in the observation group was more significant than that in the control group( P 0. 05). The incidence of CI-AKI in the time stage of t_0—t_1 and t_1—t_2 in the observation group was significantly lower than that in the control group( P 0. 05). Conclusion Fenofibrate combine with Shenfu injection can effectively improve renal function and reduce the incidence of CI-AKI after PCI in the patients with hyperuricemia coronary heart disease,and the mechanism may be that it could relieve renal oxidative stress response and inflammatory reaction.
【CateGory Index】: R541.4
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