Association study of plasma platelet-activating factor gene G994T mutation and cerebral hemorrhage
YU Min, YANG Zhi-jie, XIAO Wei-zhong, et al.Department of Neurology,Third Hospital of Peking University,Beijing 100083,China
Objective To investigate whether plasma platelet-activating factor acetylhydrolase (pPAF-AH) gene G994T mutation is associated with cerebral hemorrhage.Methods The genotype of pPAF-AH gene was analyzed in 150 patients with primary cerebral hem-orrhage and 150 controls without cerebral vascular disease with allele specific polymerase chain reaction. Results The freqencies of T allele were 3% in cerebral hemorrhage group and 4% in control group. GT heterozygote frequency in case and control group was 6.8% and 8.5% respectively.The difference between two groups was not significant. Conclusion These results suggested that pPAF-AH gene G994T mutation might not have any significant relationship with cerebral hemorrhage.
【CateGory Index】： R743.34