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Effects of acupuncture on calcitonin gene-related peptide gene expressions in the brain of migraine rats

ZHONG Guang-wei,LI Wei,DENG Gan-chu,et al.Xiang Ya Hospita l,Central South University,Changsha 410078,China  
Objective To explore the expression level of CG RP in the brain of migraine rats ,cont rol and regulate mechanism of the acupuncture to CGRP gene expression s under the finished works.To get the further exploration of the action me chanism of the acupuncture to prevent and cure migraine.Methods The model of migraine rats were repro duced in accordance with Knynihar-C slillik methods,then the rats were divided randomly into four grou ps:(1)Normal control group;(2)Model control group;(3)Acupuncture treatment group;(4)Acupuncture prevention group.The c ontent of CGRP was detected by radio-immunity analysis method.The level of expression of CGRP mRNA was measured by RT-PCR method.Results The CGRP content of the blood in the ju gular Veins:The content was constan tly kept inlower level in the normal rats.The content of model group was significantly increased(P0.01);the content of acupuncture prevent ion group and acupuncture treatment group were ap proached to that of the normal group,but compared with the model control g roup,it was significantly reduced(P0.01).The variety of CGRP mRNA expression in the brain stem and trigenminal gan glion:the lower of level was express ed in the normal control group.With comparing to the normal control group,the expression of the model group was sig nificantly increased(P0.01),and compared with the model control group,the expression of the acupuncture prevention and the treatmentio n group was significantly decreased(P0.01).Conclusions The excessive expression of CGRP in t he experiment al rat brains with migraine may be one of molecular mechanisms to trigger migraine;the controlling and regulating of acupuncture to express CGRP mRNA may be one of the mechanisms that acupuncture can efficiently preven t and treat migraine.
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