Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Modern Rehabilitation》 2003-16
Add to Favorite Get Latest Update

Parkinson-like disease induced by Meperidine hydrochloride and concentration of the monoamine neurotransmitters in the midbrain of rats

Bao Qiang Wei,Li Feng Niu,Dan Su,Staff Room of Diagnosis Fundamental Medical Institution of Liaoning Province, Shenyang 110101,Liaoning Province,China Ai Li Bao,Department of Chect,Benxi Municipal Central Hospital,Benxi 117000,Liaoning Province,China Kai Ming Li,Guang Xin Zhang,Pei Hong Cui,Xiao Ming He,Staff Room of Physiological Anatomy,Vocational Technical Institute,Liaoning University of Traditional Chinese Medicine,Shenyang 110005,Liaoning Province,China  
Aim To explore the pathogenesis of Parkinson's disease (PD).Methods The concentrations of monoamine neurotransmitters such as noradrenaline(NA), dopamine(DA), homovanillic acid (HVA), 5 hydroxytryptamine (5 HT), 5 hydroxyindoleacetic acid (5 HIAA) in the midbrain of rats induced by Meperidine hydrochloride, Naloxone and Bromocriptine were measured by using High Performance Liquid Chromatography Electrochemistry Device (HPLC ECD).Results (1)The concentrations of DA,HVA,5 HT,5 HTAA in the PD group were(211±30),(745±199),(105±21)and (13 823±7 295)ng/g respectively, with a significant difference between the PD and control groups (t=2.17-3.83, P 0.05-0.01).The concentration of NA in the PD group [(369±82)ng/g] insignificantly changed.(2) The concentrations of DA,HVA,5 HIAA in the Naloxone group were (5 624±3 323),(2 275±1 371)and (4 461±2 303)ng/g respectively, with a significant difference between the PD and Naloxone groups(t=2.17-3.21,P 0.05-0.01).(3)The concentration of DA,5 HT,5 HIAA were (5 468±2 924),(215±59) and (4 935±1 368) ng/g in the BromocriPtine group,with a significant difference between the BromocriPtine and PD groups.Conclusion Meperidine hydrochloride plays a selectively destructive role in DA neuron.
【Fund】: 辽宁科学技术基金资助(9810500304)~~
【CateGory Index】: R742.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 YANG Yan-yan NIU Chao-shi FU Xian-ming Department of Neurosurgery,Anhui Provincial Hospital,Affiliated to Anhui Medical University,Hefei 230032,China;Expressions of hHrdl,the ubiquitin-protein ligase in rat models with Parkinson's disease[J];Chinese Journal of Neuromedicine;2007-06
2 Wen Xiang Liu,Rong Wei Zhang,Shao Ji Yuan,Department of Neurosurgery, General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China;Experimental study of cardiac sympathetic nerve dysfunction in rats with unilateral Parkinson's disease[J];Chinese Journal of Clinical Rehabilitation;2004-01
3 Wang Li min,Liu Zhong lin,Tao En xiang,Wang Li juan Wang Li min,Wang Li juan,Department of Neurology,Guangdong People's Hospital,Guangzhou 510080,Guangdong Province,China Liu Zhong lin,Tao En xiang,Department of Neurology,Second Affiliated Hospital,Sun Yat sen University,Guangzhou 510080,Guangdong Province,China;Changes of monoamine neurotransmitte levels in plasma in patients with Parkinson disease[J];Chinese Journal of Clinical Rehabilitation;2005-05
4 Sun Yong-jie1,Niu Li-feng1,Zhang Guang-xin2,Su Dan1,Li Kai-ming1,Wei Bao-qiang1 1Department of Diagnosis,Liaoning Institute of Basic Medical Sciences,Shenyang 100101,Liaoning Province,China 2Department of Physiology,Vocational College,Liaoning College of Traditional Chinese Medicine,Shenyang 100101,Liaoning Province,China.;Analysis of the concentrations of monoamine neurotransmitters in serum of rats with Parkinson disease induced by meperidine hydrochloride[J];Chinese Journal of Clinical Rehabilitation;2006-26
Chinese Journal Full-text Database 4 Hits
1 HU Jingqing,WEN Zehuai,LAI Shilong (Senile Encephalopathy Institute,Guangzhou University of TCM,Guanghou 510405, China);A Preliminary Study on the Memory Attribution and Methodology in Morris Water Maze Test[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-02
2 Zhong Yougong, Zhu Xixing, Zhong Xuoli, Wang Zeren, Zhu Qiuyu, Lu Minglian(Diabetes Besearch Department, Hua Shan Hospital and Dipartment of Analytical Chemistry, School of Pharmacy, Shanghai Medical University, Shanghai);SERUM NORADRENALINE AND ADRENALINE QUANTITATION BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY[J];;1987-06
3 SUN Jin-hao,YANG Lin,GAO Ying-mao,et al.School of Medicine,Shandong University,Jinan 250012,China;The character of Parkinson disease rat model after 6-hydroxydopamine injection in different regions[J];Modern Rehabilitation;2001-23
4 Wei Baoqiang,Liaoning Basic Medical Institute,S henyang 110005,Liaoning Province,ChinaBao Aili,Clinical Laboratory,Benxi Municip al Center Hospital ,Liaoning Province,Benxi 117000,ChinaZhang Guangxin 1 ,Niu Lifeng 2 ,Su Dan 2 ,Cui Zenghong 3 ,He Xiaoming 3 ,Wang Yuqin 3 ,Zhang Kun 1 ,1 Depatment of Anatomy,2 Diagnostics and 3 Physiology,Vocational and Technological School,Liaoning College of Tra-ditional Chinese Medicine,Shenyan g 110005,Liaoning Province,China;Ultrastructural changes of substantia nigra,caudate nucleus and raphe nucleus in rat model of parkinsonism[J];Modern Rehabilitation;2003-13
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 HAN Yan,WANG Zhenfu,SUN Hong,CHEN Xianhong,CHEN Tong(Department of Neurology,Southern Building,PLA General Hospital,Beijing 100853,China);Research on the changes of neurotransmitter in brain in patients with Parkinson's disease[J];Chinese Journal of Health Care and Medicine;2009-01
2 Yan Han1,2,Zhenfu Wang1,Yang Yang3,Xianhong Chen1,Hong Sun1 1Department of Neurology in Southern Building,General Hospital of Chinese PLA,Beijing 100853,China 2The Fourth Hospital of Chinese PLA,Xining 810007,Qinghai Province,China 3Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Neurotransmitter changes in patients with Parkinson's disease detected by encephalofluctuography technology: A non-randomized control study[J];中国神经再生研究(英文版);2008-09
3 Li Ya- jun,Xie Peng,Yan Yong- Qing Li Ya- jun,Xie Peng,Department of Neurology,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,ChinaYan Yong- Qing, Epilepsy Center,Second Affiliated Hospital of Medical College,Yan'an University,Suide 718000,Shaanxi Province,China;Sympathetic skin response for evaluation of the interictal function of autonomic nerve in patients with epilesy[J];Chinese Journal of Clinical Rehabilitation;2005-09
4 Li Ya-jun1, Xie Peng1, Wang Yu-mei2, Li Yong1, Li Ping1, Zhu Yong-qing2, Kang Lin-e2, 1Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China; 2Epilepsy Center, Second Affiliated Hospital, Medical College, Yan'an University, Suide 718000, Shaanxi Province, China;Changes of serum cardiac troponin I and electrocardiograph in rats following electro-convulsion[J];Chinese Journal of Clinical Rehabilitation;2005-32
5 LI Jun-yan,YANG Ming-hui,ZHAO Guan-ying,et al.Institute of Traditional Chinese Medicine,General Hospital of PLA, Beijing 100853,China;Research on cerebral neurotransmitters of Parkinson’s disease with encephalofluctuograph technology[J];Chinese Journal of Difficult and Complicated Cases;2009-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved