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《Modern Rehabilitation》 2003-16
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Parkinson-like disease induced by Meperidine hydrochloride and concentration of the monoamine neurotransmitters in the midbrain of rats

Bao Qiang Wei,Li Feng Niu,Dan Su,Staff Room of Diagnosis Fundamental Medical Institution of Liaoning Province, Shenyang 110101,Liaoning Province,China Ai Li Bao,Department of Chect,Benxi Municipal Central Hospital,Benxi 117000,Liaoning Province,China Kai Ming Li,Guang Xin Zhang,Pei Hong Cui,Xiao Ming He,Staff Room of Physiological Anatomy,Vocational Technical Institute,Liaoning University of Traditional Chinese Medicine,Shenyang 110005,Liaoning Province,China  
Aim To explore the pathogenesis of Parkinson's disease (PD).Methods The concentrations of monoamine neurotransmitters such as noradrenaline(NA), dopamine(DA), homovanillic acid (HVA), 5 hydroxytryptamine (5 HT), 5 hydroxyindoleacetic acid (5 HIAA) in the midbrain of rats induced by Meperidine hydrochloride, Naloxone and Bromocriptine were measured by using High Performance Liquid Chromatography Electrochemistry Device (HPLC ECD).Results (1)The concentrations of DA,HVA,5 HT,5 HTAA in the PD group were(211±30),(745±199),(105±21)and (13 823±7 295)ng/g respectively, with a significant difference between the PD and control groups (t=2.17-3.83, P 0.05-0.01).The concentration of NA in the PD group [(369±82)ng/g] insignificantly changed.(2) The concentrations of DA,HVA,5 HIAA in the Naloxone group were (5 624±3 323),(2 275±1 371)and (4 461±2 303)ng/g respectively, with a significant difference between the PD and Naloxone groups(t=2.17-3.21,P 0.05-0.01).(3)The concentration of DA,5 HT,5 HIAA were (5 468±2 924),(215±59) and (4 935±1 368) ng/g in the BromocriPtine group,with a significant difference between the BromocriPtine and PD groups.Conclusion Meperidine hydrochloride plays a selectively destructive role in DA neuron.
【Fund】: 辽宁科学技术基金资助(9810500304)~~
【CateGory Index】: R742.5
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