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《Modern Rehabilitation》 2003-16
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Nerve cell apoptosis and expression of Bc1-2/Bax after cerebral contusion/laceration in human beings

Lei Duan,Wei Ping Wang,Jian Shen Zhang,Yong Zhong Ding,Department of Neurosurgery, Second Affiliated Hospital of Lanzhou Medical College, Lanzhou 730030,Gansu Province, Gansu  
Aim To study the apoptosis of nerve cells and changes of Bcl 1/Bax expression related to apoptosis in cerebral tissues after contusion/laceration in human beings.Methods Brain tissue obtained during débridement and/or frontotemporal pole incision and internal decompression from 26 patients with brain contusion/laceration.Flow cytometry (FCM) was used to examine the cell apoptosis.HE staining and immunohistochemistry were used to detect the expression of Bcl 2/Bax.The data of Glasgow coma scale of the patients were obtained.Results The apoptosis percentage was (1.2±2.1)%and (4.7±2.5)%for the patients with the GCS score of ≥6 and 6 respectively (t=3.77, P=0.001) and the apoptosis percentage was (5.2±3.5)%and (1.9±2.1)%for the patients with the time after injury of ≥24 h and 24 h respectively (t=2.34, P=0.007). The apoptosis percentage was (2.5±3.1)%and(3.6±2.1)%for the surviving patients and dead patients respectively (χ2=0.69, P=0.50). One of the 15 patients with positive Bcl 1/Bax expression and 6 of the 11 patients with negative Bcl 1/Bax expression died. The expression of Bcl 2 was correlated only to prognosis (χ2=5.161, P=0.023) but not to sex, age, GCS score, and time after injury (all P 0.05).Apoptosis percentage showed no correlation with positive expression of Bcl 2 (t=0.584, P=0.564). All the patients showed positive expression of Bax.Conclusion Apoptosis occurs in human brain after acute injury, which plays an important role in the pathologic process of brain tissue. The severity of apoptosis is related to the patients' condition and time after injury and not to prognosis.The expression of Bcl 2 is correlated with prognosis. Bcl 2/Bax is important in the signal conduction of apoptosis.
【CateGory Index】: R651.15
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