Relationship between essential hypertension and vasodilatations in the elderly
Feng Xu, Xiang Jun Bi, Jin Wang, Hua Li, Xu Hua TangFeng Xu,Xiang Jun Bi,Jin Wang,Hua Li,Xu Hua Tang, First Department of Medicine,the 173 Hospital of PLA,Huizhou 516001, Guangdong Province,China
AIM:To investigate the significance of vasodilatations in the elderly with hypertension.METHODS:Fifty four elderly patients with essential hypertension, 50 males and 4 females, with an average age of (74.9± 4.7) years (aged 68- 88), were divided into three groups of 1 (n=10), 2 (n=36), 3(n=8) grade or two groups of isolated systolic hypertension(ISH) (n=28) and non isolated systolic hypertension(NISH)(n=26). Fifty health elderly people, 47 males and 3 females with an average age of (75.4± 4.4) years (aged 70- 86), were used as controls. Radioimmunoassay and chemical colorimetry were employed to determine the content of calcitonin gene related pepide (CGRP) and nitric oxide (NO). RESULTS:The contents of CGRP and NO were (29± 9) ng/L and (28± 9) ng/L respectively in the hypertension group, significantly lower than those of the control group [(38± 9) ng/L and (39± 9) ng/L respectively].The results showed that the contents of CGRP and NO were negatively correlated with the grades of hypertension (r=- 0.500, 0.618,P 0.001). The contents of CGRP and NO in the ISH group were( 34± 9) ng/L and (32± 8) ng/L respectively, significantly lower than those of the NISH group [(23± 6)ng/L and (23± 8) ng/L respectively](t=5.183, 4.190, P 0.001).All the results showed that a highly positive correlation was found between the contents of plasma CGRP and NO in each group.
【CateGory Index】： R544.1