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《Chinese Journal of Clinical Rehabilitation》 2004-03
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Regulative function of interleukin-1 in vascular smooth muscle cell proliferat ion and hypertrophy of essential hypertension patients under arginine vasopressi n

Xue Li,Lian- You Zhao,Qing Zhang Xue Li,Qing Zhang,Department of Cardiology,Xijing Hospital of Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China Lian- You Zhao,Department of Cardiology,Tangdu Hospital of Fourth Military M edical University,Xi'an 710038,Shaanxi Province,China  
AIM:To investigate effects of interleukin- 1(IL- 1) on the activity of nitr ic- oxide synthase(NOS),nitric oxide(NO) content,cell count,protein content per cell,cell cycle analysis and cell proliferation index(PI) in artery vascular sm ooth muscle cell(VSMC) of essential hypertension and normotensive patients under arginine vasopressin(AVP). METHODS:Ten hospitalized patients with carcinoma of stomach were selected[sys tolic pressure≥ 160 mmHg( 1 mmHg=0.133 kPa) or diastolic pressure ≥ 90 mmHg] ,and their history of hypertension were five years.Mesenteric artery(2.0-2.5 c m) was extracted and tunica intima and tunica adventitia of it were peeled. RESULTS:① Under AVP,NO content and activity of NOS in VSMC of essential hype rtension patients were significantly lower than those in normotensive patients(t =-8.79,3.96;P 0.05).② Under AVP,S stage percentage,PI,cell count and protein content per cell of EH patients is significantly higher than those in normotens ive patients(t=-30.013-2.547;P 0.05).③ Under AVP+ IL- 1,NO content and a ctivity of NOS in VSMC of essential hypertension patients were significantly low er than those in normotensive patients(t=-8.791,8.96;P 0.05).④ Under AVP+ I L- 1,S stage percent,PI,cell count and protein content per cell in VSMC of esse ntial hypertension patients were significantly higher than those in normotensive patients(t=-30.527-7.359;P 0.05). CONCLUSION:① IL- 1 can’ t completely redress low activity of NOS in VSMC o f patients.② IL- 1 can′ t completely antagonize VSMC of proliferation and hyp ertrophy under AVP.
【CateGory Index】: R544.1
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