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《Chinese Journal of Clinical Rehabilitation》 2004-08
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Relationship between the protein expressions of cyclooxygenase-2 and matrix metalloproteinase-7 in high risk osteosarcoma and the related factor of prognosis such as age,gender,onset time

Ji Qing Li,Zhen Wang,Zheng Guo,Feng Guo,Zhi Yuan,Fu Cheng Ma,Pei Song Yan Ji Qing Li1,Zhen Wang1,Zheng Guo1,Feng Guo1,Zhi Yuan1,Fu Cheng Ma2,Pei Song Yan2,1Institute of Orthopaedics of PLA,2Department of Pathology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi Rpovince,China  
AIM:To detect the protein expressions of cyclooxygenase 2(COX 2) and matrix metalloproteinase 7(MMP 7) in the pathological section of paraffin in the patients with high risk and low degree of malignant osteosarcoma,in order to prove the instructional significance of differentiating the malignancy degree of osteosarcoma for the judge of prognosis. METHODS:Fifty patients,who had been definitely diagnosed to be high risk osteosarcoma(n=25) and lower malignancy degree of osteosarcoma(n=25) in recent years were selected.The protein expression of MMP 7 and COX 2 was detected with immunohistochemistry,and statistical analysis was performed. RESULTS:The protein expressions of COX 2 and MMP 7 in the high risk osteosarcoma group(60.0%and 56.0%respectively) were significantly higher than those in the low degree malignancy of osteosarcoma group(28.0%and 24.0%respectively)(P 0.05,χ2=3.98);there was significant difference between the protein expressions of OCX 2 and MMP 7 and the survival length and age of patient(P 0.05,r=0.921),but there was no significant difference among gender, size and location of tumor,time of illness,therapy,clinical staging,lymph node metastasis, onset time,etc.(P 0.05,r=0.815).There was a correlation between COX 2 and MMP 7. CONCLUSION:Protein expressions of COX 2 and MMP 7 have instructional significance in the differentiation of malignancy degree of tumor and judgment of prognosis.
【CateGory Index】: R738.1
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