Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Rehabilitation》 2004-20
Add to Favorite Get Latest Update

Establishment of rat model of osteosarcoma with lung metastasis

Zhe Yu,Qing Yu Fan,Xin Bao Hao Zhe Yu,Qing Yu Fan,Xin Bao Hao,Orthopedics Oncology Institute of Chinese PLA,Center of Orthopedic Surgery,Tangdu Hospital,Fourth Military Medical University of Chinese PLA,Xi'an 710038,Shaanxi Province,China  
AIM:To investigate the relationship of amount of inoculated cells of ostoesarcoma cell line with formation of osteosarcoma and lung metastasis. METHODS:Thirty 6 week old SD rats were divided into 3 groups.The UMR 106 cell line was injected subcutaneously into the SD rat lateral thigh at the amount of 1×105,1×106 and 1×107 separately.The growth status was observed,and the neoplastic diameters were measured every week after inoculation to build the tumor growth curve.Five weeks later,the bilateral lungs and tumors were prepared.Pathological study was made under microscope by HE staining. RESULTS:The tumors of 1×105 and 1×106 groups did not develop well,nor lung metastasis were observed;while in the 1×107 group,the incidence of tumors was 100% and 70% of them metastasized to lungs. CONCLUSION:The UMR 106 cell line has strong carcinogenic capability and high lung metastasis frequency,based on which the animal models should be established to offer a method for the animal experiments of comprehensive therapy for osteosarcoma.
【Fund】: 国家自然科学基金资助项目(30330610)~~
【CateGory Index】: R738.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 YU Zhe,FAN Qing-yu.Center of Orthopedic Surgery,Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China.;Current applications of animal model with osteosarcoma.[J];Journal of Modern Oncology;2006-01
2 Zhou Guang-xin,Zhao Jian-ning Department of Orthopaedics,Nan-jing General Hospital of Nanjing Military Area Command of Chinese PLA,Nan-jing 210002,Jiangsu Province,China;Experimental characteristics of creating animal models of osteosarcoma[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-37
【Citations】
Chinese Journal Full-text Database 4 Hits
1 HAO Xin-Bao, FAN Qing-Yu, ZHANG Dian-Zhong, QIU Xiu-Chun, YIN Jian-Ning, ZHANGHui-Zhong, WANG Xiao-Ning(Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital, Fourth Military Medical Univer-sity, Xi'an 71OO38, China);Immunotherapy of rat osteosarcoma using tumor vaccine from fusion of macrophages with osteosarcoma cells[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-12
2 ZHOU Yong,FAN Qing-yu,MABao-an,et al.Tangdu Hospital,Fourth Militar y Medical University,Xi ' an 710038,China;Evaluation the limb and joint function of the hyperthermia induced by inserted microwave antenna arrays to treatment the limb osteosarcoma[J];Modern Rehabilitation;2002-12
3 Wang Xiangru,Qian Jixian,Long Hua,Fan Degang,Wen Yanhua,Fan Qingyu,Orthopedic Oncology Institute of Chinese PLA,Tangdu Hospital,Fourth Military Medical University,Xi ' an 710038,Shaanxi Province,China;Expression of oncogene correlates with survival rate and survival quality in osteosarcma[J];Modern Rehabilitation;2003-08
4 Liao Bo,Ma Baoan,Zhang Huizhong,Long Hua,Zhang Peng,Fan Qingyu,Department of Orthopeadics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038,Shaanxi Province,ChinaChen Gang,Department of Hematology,Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004,Shaanxi Province, China;Construction and evaluation of cDNA library of osteosarcoma 9607 cells[J];Modern Rehabilitation;2003-14
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YU Zhe, FAN Qing-Yu, Ma Bao-An, HAO Xin-Bao, LONG HuaCenter of Orthopedic Surgery, Orthopedics Oncology Institute ofChinese PLA, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710038,P.R.China;Inducing Specific Antitumor Effects on Osteosarcoma by Fused Vaccine of Mouse Dendritic Cells[J];Chinese Journal of Cancer;2005-03
2 YU Zhe,FAN Qing Yu,HAO Xin Bao,LONG Hua,LIU Yun Yan,WEN Yan Hua,ZHAO HongPLA Institute of Orthopedics Oncology,Tangdu Hospital,Fourth Military Medical University,Xi’an 710038,China;Immunotherapy of rat osteosarcoma using tumor vaccine from fusion of dendritic cells with the osteosarcoma cells[J];Journal of The Fourth Military Medical University;2004-17
3 YU Zhe,FAN Qing-yu,ZHANG Ting(Center of Orthopedic Surgery,Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital,Xi’an,Shaanxi,710038,China);Establishment of Rat Model of Osteosarcoma[J];Progress In Veterinary Medicine;2005-02
4 CUI Jian-ling,SUN Jun-hui,GUO Zhi-yuan,et al.Department of Radiology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,P.R.China;A Primary Experimental Study to Identify Necrosis of Sprague-Dawley Rat Osteosarcoma by DWI[J];Radiologic Practice;2005-11
5 WEI Xing,SHI Yamin,Zhu Fangzheng,et al.Department of Orthopedics,the First Affiliated Hospital of PLA General Hospital,Beijing,100037,China;Evaluation of the limb function after treatment of malignant bone tumors of the knee by microwave hyperthermia[J];Chinese Journal of Bone Tumor and Bone Disease;2008-06
6 YU Zhe,FAN Qing-yu.Center of Orthopedic Surgery,Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China.;Current applications of animal model with osteosarcoma.[J];Journal of Modern Oncology;2006-01
7 Ji Qing Li,Zhen Wang,Zheng Guo,Feng Guo,Zhi Yuan,Fu Cheng Ma,Pei Song Yan Ji Qing Li1,Zhen Wang1,Zheng Guo1,Feng Guo1,Zhi Yuan1,Fu Cheng Ma2,Pei Song Yan2,1Institute of Orthopaedics of PLA,2Department of Pathology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi Rpovince,China;Relationship between the protein expressions of cyclooxygenase-2 and matrix metalloproteinase-7 in high risk osteosarcoma and the related factor of prognosis such as age,gender,onset time[J];Chinese Journal of Clinical Rehabilitation;2004-08
8 Tao Huang,Gang Lü,Da Xin Gao,Mao Wei Yang,Yan Feng Wang Tao Huang,Gang Lü,Da Xin Gao,Mao Wei Yang,Yan Feng Wang, Department of Orthopaedics,First Affiliated Hospital,China Medical University,Shenyang 110001,Liaoning Province,China;Significance of Fas and bcl 2 expressions on the occurrence and prognosis of osteosarcoma[J];Chinese Journal of Clinical Rehabilitation;2004-29
9 Tao Huang,Gang Lü,Da-Xin Gao,Mao-Wei Yang,Yan-Feng Wang Tao Huang,Gang Lü,Da-Xin Gao,Mao-Wei Yang,Yan-Feng Wang,Department of Orthopedics,First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China;Expression and function of Caspase-3 and Fas in the occurrence and development of osteosarcoma[J];Chinese Journal of Clinical Rehabilitation;2004-35
10 Huang Tao,LüGang,Gao Da xin, Yang Mao wei,Wang Yan feng Huang Tao,LüGang,Gao Da xin, Yang Mao wei,Wang Yan feng,Department of Orth opaedics,First Affiliated Hospital,China Medical University,Shenyang 110001,Liao ning Province,China;Expression of PTEN and P53 in osteosarcoma and their effect on prognosis[J];Chinese Journal of Clinical Rehabilitation;2005-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YU Zhe, FAN Qing-Yu, Ma Bao-An, HAO Xin-Bao, LONG HuaCenter of Orthopedic Surgery, Orthopedics Oncology Institute ofChinese PLA, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710038,P.R.China;Inducing Specific Antitumor Effects on Osteosarcoma by Fused Vaccine of Mouse Dendritic Cells[J];Chinese Journal of Cancer;2005-03
2 LI Qiong, WU Ming-Fu, SONG An-Ping, WEI Jun-Cheng, XU Gang, LU Yun-Ping, MA Ding Department of Obstetrics andGynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science andTechnology,Wuhan, Hubei, 430030,P. R. China;Expression of Ezrin and E-cadherin in Invasive Ductal Breast Cancer and Their Correlations to Lymphatic Metastasis[J];Chinese Journal of Cancer;2006-03
3 Yu Suojing,XiaoLuwei,Wu Chengliang Zhejiang College of TCM,Hangzhou(310053);A Phenomenon of Cell “Contra-divison”[J];Journal of Zhejiang College of Tcm;2004-05
4 FAN Qing-Yu(Center of Orthopedics Surgery of Chinese PLA,Tangdu Hospital, Fourth Military Medical Univer-sity, Xi'an 71OO38, China);Current concepts and principles of treatment for tumor of muscular-skeletal system[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-12
5 FAN Qing-Yu, MA Bao-An, ZHOU Yong,ZHANG Mng-Hua, YE Jun, QIU Xiu-Chun,ZHENG Lian-He, LIU Zhen-Dong, SHENGWan-An, LI Jun(Center of orthopedics Surgery and Orthopedics On-cology Institute of Chinese PLA, Tangdu Hospital,Fourth Military Medical University, X;Clinical use of microwave-induced hyperthermia in the management of malignant or aggressive bone tumors of extremities[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-12
6 HAO Xin-Bao, FAN Qing-Yu, ZHANG Dian-Zhong, QIU Xiu-Chun, YIN Jian-Ning, ZHANGHui-Zhong, WANG Xiao-Ning(Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital, Fourth Military Medical Univer-sity, Xi'an 71OO38, China);Immunotherapy of rat osteosarcoma using tumor vaccine from fusion of macrophages with osteosarcoma cells[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-12
7 YU Zhe,FAN Qing-yu,ZHANG Ting(Center of Orthopedic Surgery,Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital,Xi’an,Shaanxi,710038,China);Establishment of Rat Model of Osteosarcoma[J];Progress In Veterinary Medicine;2005-02
8 HUO Nai-rui~(1),MENG Li-mei~( 2) (1.College of Food Science and Engineering, Shanxi Agricultural University,Taigu,Shanxi,030801,China; 2.Taiyuan Husbandry and Veterinary College of Shanxi Agricultural University,Taiyuan,Shanxi, 030001,China);Applicational Development of Cell Fusion Techniques[J];Progress In Veterinary Medicine;2005-03
9 HUO Nai-rui~a,HAN Ke-guang~b (Shanxi Agricultural University a.College of Food Science and Engineering;b.College of Animal Science and Technology,Taigu 030801,Shanxi,China);Cell Fusion Technique: its Development and Applications[J];Acta Laser Biology Sinica;2006-02
10 ;RECENT ADVANCES OF DENDRITIC TUMOUR-CELL FUSION IN ANTITUMOR IMMUNITY STUDY[J];Acta Anatomica Sinica;2003-06
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 FAN Qing-Yu, MA Bao-An, ZHOU Yong,ZHANG Mng-Hua, YE Jun, QIU Xiu-Chun,ZHENG Lian-He, LIU Zhen-Dong, SHENGWan-An, LI Jun(Center of orthopedics Surgery and Orthopedics On-cology Institute of Chinese PLA, Tangdu Hospital,Fourth Military Medical University, X;Clinical use of microwave-induced hyperthermia in the management of malignant or aggressive bone tumors of extremities[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-12
2 HU Yun-Sheng, FAN Qing-yu, ZHOU Yong, et al. Orthopaedic Oncology Institute of PLA,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China;Analyses in construction and mechanics of allogenic bone matrix gelatin impregnated with bone cement[J];Modern Rehabilitation;2001-24
3 Fan Qingyu, Ma Baoan, Guo Ailin, et al.Department of Orthopedic Surgery,Second Hospital,Fourth Military Medical University,Xian 710038.;Treatment of malignant or aggressive bone tumors with microwave induced hyperthemia[J];Chiese Journal of Surgery;1997-08
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved