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《Chinese Journal of Clinical Rehabilitation》 2004-31
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Expression of ciliary neurotrophic factor of spinal cord motoneuron after sciatic nerve injury and changes after acupuncture intervention in rats

Shu-Rong Wang,Ya-Mei Dai,Xiu-Lan Hao,Department of Neurology,First Clinical Medical College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Zhong-Ren Sun,Department of Neurology,Second Clinical Medical College,Heilongjiang University of Traditional Chinese Medicine,Harbin 150013,Heilongjiang Province,China  
AIM:To observe the expression of ciliary neurotrophic factor(CNTF) of spinal cord motoneuron after sciatic nerve injury and changes after the intervention of acupuncture and nerve growth factor(NGF), and investigate the mechanism of plerosis with acupuncture after nerve injury. METHODS:A total of 160 Wister rats were divided into five groups, including electric needle group,medicine group(NGF),handle needle group,model group and sham operation group.The models of surrounding nerve injury were established by forceps clip of sciatic nerve,and immunohistochemistry combining with photoelectric lens was used to stain.According to video analysis system,various intervention methods were assayed,and the amount and absorbance(A) of positive CNTF spinal cord motoneuron were analyzed at different time. RESULTS:The amount and A of positive CNTF spinal cord motoneuron in waist after sciatic nerve injury were decreased from the seventh day,obviously from the 14th day, the lowest from the 21th day and recovered from the 28th day. The amount of positive neuron was(61.42±0.42)%,(50.94±2.96)%,(42.72±4.51)%and(49.37±2.70)%respectively in CNTF model group.The injured side was obviously as compared with relative side(P 0.05). Acupuncture and NGF treatment could reduce the death amount of neuron, decrease the degree of A(P 0.05) and relieve the morphological changes of neuron swelling and degeneration. CONCLUSION:Acupuncture and NGF treatment can enhance the survival of spinal cord motoneuron, accelerate the recovery of endogenetic CNTF,relieve the degeneration and necrosis of neuron,and reduce the death of neuron.
【CateGory Index】: R745
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