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《Chinese Journal of Clinical Rehabilitation》 2004-35
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Expression and function of Caspase-3 and Fas in the occurrence and development of osteosarcoma

Tao Huang,Gang Lü,Da-Xin Gao,Mao-Wei Yang,Yan-Feng Wang Tao Huang,Gang Lü,Da-Xin Gao,Mao-Wei Yang,Yan-Feng Wang,Department of Orthopedics,First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China  
AIM:To study the expression of Caspase-3 and Fas in osteosarcoma and its possible role in the occurrence and development of osteosarcoma. METHODS:Caspase-3 and Fas were detected with SP immunohistochemical method in 38 samples of osteosarcoma and 20 of osteochondroma collectd from the First Affiliated Hospital of China Medical University from May 1995 to November 2002. RESULTS:The positive rate of Caspase-3 was 53%(20/38) in osteosarcoma and 85%(17/20) in osteochondroma.The former was significantly lower than the later(χ2=5.944,P 0.05).The positive rate of Fas was 74%(28/38) in osteosarcoma significantly lower than that in osteochondroma(95%, 19/20)(χ2=3.874,P 0.05).The expression of Caspase-3 and Fas in osteosarcoma had remarkably positive correlation(r =0.391,P 0.05). CONCLUSION:It is suggested that the decreased expression of Caspase-3 and Fas relate to the occurrence and development of osteosarcoma and they are correlative.
【CateGory Index】: R738.1
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