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《Chinese Journal of Clinical Rehabilitation》 2005-13
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Effects of oxiracetam on activity of daily living and cognitive function of convalescent patients with hypertensive cerebral hemorrhage after operation

Tian Xue wen1,Tong Xiu tian2,Dong Man li3,Pan Hao1,Wang Xi ling1,1Institute of Neurosurgery,Xijing Hospital,Fourth Military Medical University of Chinese PLA,Xi'an 710033,Shaanxi Province,China;2Red Cross Hospital of Yuncheng,Yuncheng 274700,Shandong Province,China;3Provincial Government Hospital of Shaanxi,Xi'an 710054,Shaanxi Province,China  
AIM:To observe the efficacy of oxiracetam in activity of daily living(ADL) and cognitive function of patients with hypertensive cerebral hemorrhage after operation during restoration period with a randomized,double blind and placebo controlled method and study the reliability. METHODS:The experiment was finished in the Institute of Neurosurgery,Xijing Hospital,Fourth Military Medical University of Chinese PLA,from March to September 2004.Totally 159 Patients with hypertensive intracerebral hemorrhage 7 days after surgical treatment with stable vital signs were selected.They were randomly divided into oxiracetm group(82 cases) and placebo group(77 cases).They received treatment of either oxiracetm or placebo 6 tablets daily for 3 months.The ADL of patients was assessed by using Barthel Index(BI),neurological functional deficit scores(NFDS),and cognitive function was assessed with Hasagawa dementia scales(HDS) every month after treatment. RESULTS:In the study, only 148 cases received 3 month follow up.Among them,76 patients received oxiracetam and 72 patients received placebo.①BI in oxiracetam group(89.2±14.3,93.3±14.2,97.3±12.3) 1,2 and 3 months after treatment was significantly effective than that in placebo group(75.8±29.3,81.3±27,79.8±25.3),and there was significant difference(t= 3.26, P 0.05).②NFDS in oxiracetam group (6.7±4.7) after 1 month was significantly effective than that in placebo group (9.6±6.8),and there was significant difference between the two groups after 2 and 3 months.③HDS at 1, 2 and 3 months after treatment was 29.4±4.6,30.4±4.7 and 31.4±3.6 respectively in oxiracetam group,27.6±6.4,27.9±5.1 and 28.6±5.4 in placebo group,and there was significant difference(t=4.15,P 0.05). ④The incidence of adverse events in oxiracetam treated patients was 4.9%(3/76),and in placebo controlled patients was 3.7%(1/72), but there was no significant difference(t=1.17,P 0.05). CONCLUSION:Oxiracetam of 3 months can accelerate the recovery of ADL,cognitive function and neural function after operation with good reliability in patients with hypertensive intracerebral hemorrhage.
【CateGory Index】: R651
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