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《Chinese Journal of Clinical Rehabilitation》 2005-15
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Correlation of resistant starch with blood glucose and lipid of type 2 diabetic rats

Ding Yu-qin, Kong San-nan, Zheng Jin-feng, Department of Nutrition, Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA, Nanjing 210002, Jiangsu Province, China  
AIM: To observe the influence of resistant starch on blood glucose, blood lipid and other biochemical indicators in type 2 diabetic rats, so as to provide experimental evidence for seeking suitable food for diabetic patients. METHODS: Thirty Wistar rats were divided into four groups at random: normal control group (n=7), diabetic control group, resistant starch group (n=8) and digestible starch group (n=8).Rats in the normal control group were fed with command diet, while those in the diabetic control group, resistant starch group and digestible starch group were fed with high glucose and high lipid diet.After establishment of type 2 diabetic rat models, rats in the digestible starch and resistant starch groups received gastric perfusion of digestible starch and potato starch 6 g/kg per day (diluted with distilled water), while gastric perfusion of distilled water was given to those in the other two groups. The heads of the rats were cut down for blood after 4 weeks, then the levels of blood glucose,glycosylated hemoglobin (HbA1c), insulin and other biochemical indicators of rats in each group were determined. RESULTS:The levels of blood glucose, HbA1c,blood lipid (total cholesterol, triacylglycerol) and uric acid were significantly higher in the rats of the diabetic control group than in the normal control group (P 0.05 to 0.01).The levels of blood glucose,total cholesterol and blood urea nitrogen of rats in the resistant starch group [(17.1±3.4), (4.07±0.87),(5.55±0.50) mmol/L] were obviously lower than those in the digestible starch group [(21.4±3.1), (4.99±1.09), (6.27±0.82) mmol/L] and diabetic control group [(21.9±3.0),(5.02±1.00),(7.72 ±0.81) mmol/L](P 0.05 to 0.01).There were insignificant differences in the levels of serum protein, calcium, phosphorus and magnesium among the groups (P 0.05). CONCLUSION: Resistant starch can reduce the levels of blood glucose, blood lipid and blood urea nitrogen of type 2 diabetic rats, indicating that resistant starch has the effect of alleviating diabetic symptoms, and may protect its renal function.
【CateGory Index】: R587.1
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