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《Chinese Journal of Clinical Rehabilitation》 2005-15
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Influence of preventive moxibustion on inflammatory cells and local feet swelling of rats with adjuvant arthritis at early and secondary stages

Li Xiao-hong1, Zhang Lu-fen1, Guo Shun-gen2, Xie Jie-ping1, Li Xue-wu1,Li Hui3, Zhai Jing-hui1, Li Jing-dao1, Zhu Wen-lian1, Zhao Fu-jian2, Zhao Li-yun2, 1School of Acupuncture, 2School of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; 3Department of Acupuncture, Sino-Japanese Friendship Hospital, Beijing 100029, China  
AIM: To observe the effects of preventive moxibustion on the local joint swelling and inflammatory factors of interleukin-1-beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in rats with adjuvant arthritis (AA) at early and secondary stages. METHODS:The experiment was carried out in the laboratory of acupuncture mechanism,School of Acupuncture, Beijing University of Chinese Medicine from August to December 2004.Forty-eight Wistar rats were divided into 6 groups with the method of randomly number table: normal group, model early group, preventive moxibustion early group, model secondary group, preventive moxibustion secondary group and preventive moxibustion normal group with 8 rats in each group.Rats in the normal group were not made into models and received no preventive moxibustion; Rats in the model early group were made into AA models by using subcutaneous injection of Zhao's complete adjuvant (0.1 mL) at palm of right hindfoot, and the samples were prepared on the 3rd day; Rats in the preventive moxibustion early group were made into AA models after muxibustion at Tachui acupoint once every other day, one moxa-cone every time for 8 times,and the samples were prepared on the 3rd day;Rats in the model secondary group were made into AA models, and the samples were prepared on the 16th day; Rats in the preventive moxibustion secondary group were made into AA models after muxibustion, and the samples were prepared on the 16th day; Rats in the preventive moxibustion normal group were treated with moxibustion, and then the samples were prepared after that. Radioimmunoassay and cubage measurement of rats' feet were performed to observe the effects of preventive moxibustion on the feet swelling rate and serum IL-1βand TNF-αin AA rats at early and secondary stages. RESULTS: All the 48 rats were involved in the analysis of results.①The right feet swelling rate at early phase was higher in the model group and preventive moxibustion group than in the normal group [(2.128±0.262)%, (1.301±0.250)%, (0.011±0.018)%, F=26.001, P 0.01]; The right feet swelling rate at secondary phase was higher in the model group and preventive moxibustion group than in the normal group [(1.736±0.165)%,(1.156±0.230)%,(0.009±0.018)%, P 0.01], and it was relieved more obviously in the preventive moxibustion group than in the model group (P 0.05). ②The serum IL-1βlevel in the model early and secondary groups were obviously increased as compared with that in the normal group [(0.358±0.047), (0.281±0.012), (0.200±0.204) μg/L, P 0.01], and the increasing tendency was relieved in the preventive moxibustion early group [(0.295±0.018) μg/L], and the serum IL-1βlevel in the preventive moxibustion secondary group was close to the normal level [(0.245±0.021) μg/L, P 0.05]. ③The TNF-αlevels in the model early and secondary groups preventive moxibustion early group were obviously increased as compared with those in the normal group [(0.950 ±0.139), (0.844±0.163), (0.832±0.145), (0.573±0.096) μg/L, P 0.01], and it was markedly decreased in the preventive moxibustion secondary group as compared with the model secondary group [(0.714 ±0.066) μg/L, P 0.05]. CONCLUSION:Preventive moxibustion can alleviate the feet swelling rate of AA rats at both early and secondary phases, which may be related with its regulative effect on the contents of serum inflammatory factors of IL-1βand TNF-α.
【Fund】: 国家自然科学基金课题(90209026);; 教育部优秀青年骨干教师课题~~
【CateGory Index】: R245
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