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《Chinese Journal of Clinical Rehabilitation》 2005-35
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Anti-oxidation effect of gypenosides in aged rats

Cai Taisheng~1, Zhang Shan-feng~2, Wang Ming-chen~2,~1Department of Biochemistry, Hebi Vocational Technology School, Hebi 458030, Henan Province, China; ~2Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Zhengzhou University, Zhengzhou 450045, Henan Province, China  
AIM: To observe the antioxidation effect of gypenosides in aged rats and study its mechanism of delaying aging. METHODS: The experiment was done in the Medical College of Zhengzhou University from March 2004 to February 2005. Fifty male SD rats at 18 months of age were selected and randomized into five groups with 10 in each group: distilled water in blank control group (once a day), 20 mg/kg ginseng saponins in ginseng saponin group(once a day), 40, 20 and 10 mg/kg gypenosides in three treatment groups (once a day). Thirty days after treatment, both the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in serum and brain were assayed, and immune organ index were determined. RESULTS: All the 50 rats were involved in the result analysis. ①Effect of gypenosides on thymus index and spleen index in aged rats: Thymus index and spleen index in the 40 mg/kg and 20 mg/kg gypenosides groups were higher than those in the control group[40 mg/kg group: 18.98±1.95, 22.12 ±2.41; 20 mg/kg group: 17.98±1.64,22.89±1.98; control group: 16.02±2.03, 18.79±2.37; P0.05].②Effects of gypenosides on SOD activity and MDA content in serum and brain: The activity of SOD in serum was significantly increased in the 20 mg/kg and 40 mgAg gypenosides groups, and the activity of SOD in brain was significantly higher than that in the control group [(176.24±19.56), (154.35±17.23), (113.14±13.56)kNu/L],P0.01], while the content of MDA in serum was decreased remarkably in the 40 mgAg gypenoside group, and the MDA content in brain of the 20 mgAg and 40 mg/kg groups was lower than that in the control group[(102.24+11.32), (132.54±12.03),(199.32±20.15)μmol/L,P0.01]. CONCLUSION: Gypenosides can strengthen the capability of anti-aging so as to delay aging in aged rats.
【CateGory Index】: R285
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