Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Rehabilitation》 2005-42
Add to Favorite Get Latest Update

Relationship between perioperative hemodynamic changes and myocardial damage during orthotopic liver transplantation

Liu De-zhao, Hei Zi-qing, Luo Gang-jian, Li Shang-rong, Ma Wu-hua, Luo Chen-Fang, Department of Anesthesiology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China  
AIM: To observe the changes of periopeative hemodynamics and various myocardial enzymes during orthotopic liver transplantation (OLT), and investigate the association between hemodynamics and myocardial damage.METHODS: Twenty patients with end disease of hepatism, whowere selected from the Third Affiliated Hospital of Sun Yat-sen University between June and September 2004, were scheduled for OLT under combined general anesthesia. The hepatic duct, left and right hepatic arteries and portal veins were ligated routinely, the superior and inferior vena cavas were clipped to close from front to behind with the interruption claw of vena cava, supplied liver anastomosis was conducted after diseased liver was cut. The cava was anastomosed firstly, and the stoma was shaped as inverted triangle, and then portal veins were anastomosed, the liver blood supply was recovered to enter the new liver period, and then hepatic arteries and bile duct were anastomosed in order. Blood samples were drawn from central vein at preoperative stage, 30 minutes after anhepatic stage, 30 minutes after reperfusion stage, the end of surgery and 24 hour after operation respectively, the myocardial zymogram was determined, meanwhile, perioperative heart rate, cardiac output, central venous pressure and mean arterial blood pressure were measured. RESULTS: According to intention-to-treat analysis, all the 20 patietns entered the analysis of results. ① Postoperative recovery: All patients received orthotopic liver transplantation successfully. The duration of operation was (335.74±74.04) minutes, and the time of anhepatic phase was (36.37±7.90) minutes. 3 Patients suffered from heart failure among whom 2 died after OLT, the others all recovered very well. ② Changes of hemodynamics: The cardiac output and central venous pressure were decreased at the anhepatic stage (P 0.01) and increased at the reperfusion stage (P 0.01 or P 0.05). The mean arterial blood pressure once decreased while blocking and opening the inferior vena cave, but it could keep stable after applying some vasoactive drugs. Heart rate increased while entering the anhepatic stage, when it came into the reperfusion stage, heart rate increased in the early period and rebounded to the preoperative level. ③Changes of myocardial zymogram: Compared with the preoperative stage: Only myohaemoglobin was significantly increased (P 0.01) at 30 minutes after anhepatic stage, and others had no significant differences (P 0.05) At 30 minutes after reperfusion and the end of the surgery, all of the values of myocardial zymogram were significant increased And at the phase of 24 hour after operation, all the values increased significantly (P 0.05 or 0.01) except that lactate dehydrogenase isoenzyme had no obvious changes (P 0.05). Compared with the stage of 30 minutes after reperfusion, aspartate aminotransferase, lactate dehydrogenase, lactate dehydrogenase isoenzyme and alpha-hydroxybutyrate dehydrogenase at 24 hour after operation were significantly decreased (P 0.05), and creatine kinase was significantly increased (P 0.05), and isoenzyme of creatine kinase and myohaemoglobin had no significant differences (P 0.05). CONCLUSION: After reperfusion high hemodynamics occurred and myocardial zymogram increased generally, and myocardial zymogram recovered at 24 hours after OLT, which indicated that there is divergence phenomenon between hemodynamics and myocardial zymogram.
【Fund】: 国家自然科学基金资助项目(30271254);; 广东省科技计划项目(2004B35001005)~~
【CateGory Index】: R657.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Xie Jin-min, Pan Ming-xin, Zhang Hui-ying, et al Department of General Surgery, Zhujiang Hospital Affiliated to Southern Medical University, Guangzhou 510282, Guangdong Province, China;Establishment and evaluation of orthotopic liver transplantation models without veno-venous bypass in miniature pigs[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-04
2 Yu Xiang-hong, Wu Xiao-zhi, Chen Guo-zhongDepartment of Anaesthesiology, Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou 350025, Fujian Province, China;Effect of retrograde perfusion on hemodynamics in orthotopic liver transplantation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-31
Chinese Journal Full-text Database 2 Hits
1 Hei Ziqing,Huang Wenqi,Chen Binxue,et al Department of Anesthesia,First Affiliated Hospital,Sun Yan-Sen Medical University,Guangzhou 510080;Hemodynamic Changes and Treatments of Early Anhepatic and Reperfusion Phase during Liver Transplantation with Veno-Venous Bypass[J];THE JOURNAL OF CLINICAL ANESTHESILOLGY;2000-06
2 Chen Guihua,Lu Minqiang,He Xiaoshun,et al.Transplantation Surgery,The First Affiliated Hospital of ZhongShan University,Guangzhou 510080,China;The modifying piggyback liver transplantation:report of 69 cases.[J];Chinese Journal of Practical Surgery;2002-07
Chinese Journal Full-text Database 10 Hits
1 YUAN Yun-Fei1,CUI Bo-Kang1,ZHANG Ya-Qi1,LI Sheng-Ping1,CHEN Min-Shan1 ,GUO Rong-Ping1,LIN Xiao-Jun1,CHEN Gui-Hua2,LI Jin-Qing1 1.Department of Hepatobiliary Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China 2.Department of Liver Transplantation Surgery,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,510630,P.R.China;Preliminary Study on Orthotopic Liver Transplantation for Treatment of Advanced Hepatocellular Carcinoma Without Extra-hepatic Metastasis——A Report of 10 cases[J];Chinese Journal of Cancer;2004-09
2 WANG Jian-bin(Intensive Care Unit,Huaibei People's Hospital,Huaibei 235000,China);Eearly complication management in intensive care period after orthotopic liver transplantation[J];Journal of Bengbu Medical College;2007-05
3 Wang Chuanxi~1,Hei Ziqing~2,Luo Chenfang~2,CHI Xinjin~2.1 Guangzhou Blood Center,Guangzhou 510095,China;2 Department of Anesthesiology,the Third(Affiliated) Hospital of Sun Yat-sen University;Effect of Aprotinin on perioperative vasopressor use,blood and liquid requirement in severe hepatitis patients undergoing liver transplantation[J];Chinese Journal of Blood Transfusion;2006-03
4 ;改良背驮式肝移植手术巡回护士的配合[J];Today Nurse;2009-06
5 CHEN Huan-wei, ZHEN Zuo-jun, SU Shu-ying, XU Zhuo-ming, FEI Lin, JI Yong Department of Hepatobiliary Surgery, First People's Hospital of Foshan, Foshan 528000, China;Clinical experience with13cases of orthotopic liver transplantation[J];Journal of First Military Medical University;2004-04
6 SU Shu-ying, CHEN Huan-wei, ZHEN Zuo-jun, XU Zhuo-ming, JI Yong Department of Hepatobiliary Surgery, First People's Hospital of Foshan, Foshan 528000, China;Postoperative complications after orthotopic liver transplantation: clinical analysis of 18 cases[J];Journal of First Military Medical University;2004-08
7 LIANG Ning,PAN Jin-fei,QIN Wen-bo,et al.The people's Hospital of Gungxi Zhuang Autonomous Region (Nanning 530021);Anesthetic management of both the early anhepatic phase and the early reperfused phase of the innovative orthotopic liver taransplantation[J];Guangxi Medical Journal;2004-12
8 ZHOU Jie,LIN Jian-hua,CUI Zhong-lin,ZHANG Si-yun,WANG Yu,ZHANG Guo-wei,LIN Yi-xiong Department of Hepatobiliary Surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Review of 105 cases of orthotopic liver transplantation and the prospect[J];Journal of Southern Medical University;2009-07
9 LI You-sheng, LI Ning, LI Yuan-xin,LUO Kai, LI Wei-su, NI Xiao-dong, ZHU Liang, JIANG Feng, LI Jie-shou (Research Institute of General Surgery, Nanjing General Hospital of Nanjing Command,Nanjing 210002, Jiangsu,China);Procurement and preservation of combined small intestine and liver grafts from non-heart beating cadaveric donor[J];Journal of Medical Postgraduates;2004-08
10 Hei Ziqing, Gan Xiaoliang, Luo Gangjian, et al. Department of Anesthesiology, Third Affiliated Hospital,Zhong Shan University, Guangzhou 510630 CHINA;Changes of coagulation function during in orthotopic liver transplantation in patients with severe hepatitis and liver cancer[J];The Journal of Clinical Anesthesiology;2006-05
Chinese Journal Full-text Database 10 Hits
1 YANG Jin-cheng, JI Xi-qing, LI Chao-long, LIN Jian-hua, LIU Xing-guoDepartment of Hepatobiliary and Vascular Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.;Impact of early-stage hepatic ischemia-reperfusion injury on other organs of rats[J];Journal of First Military Medical University;2004-09
2 Gu Weili, Zhuang Simin, Azuma Takaski, et al. Department of Hepatobiliary Surgery, Guangzhou First People's Hospital, Guangzhou 510180;Two operation procedures for bile duct reconstruction of liver transplantation[J];Guangdong Medical Journal;2002-08
3 QING De-ke 1, HAN Ben-li 2 (1.Hepatobiliary Surgery Center of Kunming General Hospital of PLA, Chengdu Command, Kunming 650032, China; 2.Instiute of Hepatobiliary Surgery of PLA,Southwest Hospital, The Third Military Medical University, Chongqing 400038, China);An Experimental Research on Controlled Fluid Infusion at Anhepatic Phase in Miniature Swine Undergone Orthotopic Liver Transplantation Operation[J];Journal of Guiyang Medical College;2005-03
4 HUANG Zhe-yong, JIANG Shi-sen, TANG Yi (Department of Cardiology, Clinical School of Medical College of Nanjing University/ Nanjing General Hospital of Nanjing Command, Nanjing 210002, Jiangsu, China);Impact of severity of coronary lesion on left ventricular end diastolic pressure[J];Journal of Medical Postgraduates;2004-11
5 ZHANG Lei, ZHANG Wen-tong, LI Yan, et al. Department Surgery Pediatrical, Qilu Hospital, Shandong Univrsity, Jinan 250012. China.;A New Established Model of Liver Warm Ischemia-Reperfusion in Rat[J];Journal of Clinical Pediatric Surgery;2005-05
6 QIU Wei-hua 1,Bingsen Zhou2,Dana Darwish2,Peiguo G.Chu3,Frank Luh2,CHEN Hao1,YANG Wei-ping 1,LI Hong-wei 1,Yun Yen2(1Center of Organ Transplantation,Ruijin Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai200025,China;2Department of Medical Oncology & Therapeutic Research,3Department of Pathology,City of Hope National Medical Center,Duarte,CA,91010,USA);Role of STAT3 in Inhibition of VEGF by S-Adenosylmethionine in HepG2[J];Journal of Shanghai Jiaotong University(Medical Science);2006-06
7 CHEN Si-qin reviewer WANG Ying-wei reviser(Department of Anesthesiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China);Advance in clinical application of methylene blue[J];Journal of Shanghai Jiaotong University(Medical Science);2008-02
8 ZHOU JUN-FU1, CHEN JIA-XI, SHEN HAN-CHAO, AND CAI DONG The Second Affiliated Hospital, Medical College of Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China;Abnormal Reactions of Free Radicals and Oxidative Damages in the Bodies of Patients With Chronic Glomerulonephritis[J];生物医学与环境科学(英文版);2002-03
9 ZU Cun~1,WANG Pei-hong~2,XIE Jian-guo~1,FAN Wei~1,LI Bo~1 1: Center of Liver Transplantation,West China Hospital,Sichuan University,Chengdu,610041;2: Center of Abdominal Surgery of PLA,Department of General Surgery,General Hospital of Chengdu Military Command,Chengdu,610083.;Establishment of an animal model of orthotopic liver transplantation with modified technique in rats[J];Medicial Journal of National Defending Forces in Southwest China;2005-06
10 Yuan-Yuan Yue, Zhi-Jie Feng, Department of Gastroenterology, the Second Hospital Affiliated to Hebei Medical University, Shijiazhuang 050000, Hebei Province, China;Hepatic ischemia reperfusion injury and calcium overload[J];World Chinese Journal of Digestology;2008-32
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 Zhang Qing-jun,Pan Ming-xin,Kong Fan-dong,Yao Kun-hou,Gao Yi Department of Hepatobiliary Sur-gery,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,Guangdong Province,China;Establishment and evaluation of living donor liver transplantation models in dogs[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-05
2 Xie Jin-min1, Gao Yi2, Pan Ming-xin2, Kong Fan-dong2, Yao Kun-hou2, Wang Qiong21Department of General Surgery, the 474 Hospital of Chinese PLA, Urumchi 830011, Xinjiang Uygur Autonomous Region, China;2Department of General Surgery, Zhujiang Hospital of Southern Medical University, Guang-zhou 510282, Guangdong Province, China;Immune tolerance to porcine liver transplantation induced by pre-infusion of (60)~Coγ-treated donor lymphocyte[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-18
3 Pan Ming-xin, Kong Fan-dong, Zhang Qing-jun, Yao Kun-hou, Gong Du-hui, Wang Qiong, Gao YiDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China;Establishment of acute rejection models of orthotopic liver transplantation in allogeneic minipigs[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-31
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Ping 1,PENG Zhi-ying 1,LIU Guan-jian 2 (1 The Dept.of Lab.Medicine,The First University Hospitak,WCUMS;2 The Dept.of Clinical Epidemiology, The First School of Medicine WCUMS,Chengdu,610041 China);The Systematic Review of Cardiac Markers Application[J];West China Medical Journal;2001-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved