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《Chinese Journal of Clinical Rehabilitation》 2006-35
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Interventional effect of fructus psoraleae compound preparation on postmenopausal osteoporosis

Wang Quan-quan1, Chen Hai-lin1, Zong Fang1, Huang Hui-min2, Zhang Mao-sen3 1Engineering College of Nanjing Agricultural University, Nanjing 210031, Jiangsu Province, China; 2First Hospital Affiliated to Nanjing Medical University, Nanjing 210039, Jiangsu Province, China; 3Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China  
OBJECTIVE: More and more attention was drawn to the treatment of postmenopausal osteoporosis (PMO) by traditional Chinese medicine. To probe into the mechanism in treatment of PMO by Chinese compound preparation of fructus psoraleae and its prospect. DATA SOURCES: A computer-based search was conducted in CNKI for articles related to fructus psoraleae and PMO published between November 1994 and December 2004 with the of "fructus psoraleae, postmenopausal osteoporosis", and the language was limited to Chinese. STUDY SELECTION: Data were checked in the first trial. Inclusion criteria: ① The mechanism of fructus psoraleae in the treatment of PMO. ② Research on the possible mechanism of fructus psoraleae in the treatment of PMO. Exclusion criteria: Repetitive studies, reviews and papers related to osteoporosis but not PMO. Papers were included without considering they were randomised, control or blind. DATA EXTRACTION: Of 172 relevant literatures, 12 ones were in accordance with the inclusion criteria, and 160 papers were excluded, including 145 clinical or experiment reports about non-PMO and medicine without the component of fructus psoraleae, 12 reviews as well as 3 repetitive studies. DATA SYNTHESIS: ① Fructus psoraleae compound preparation could prevent and treat PMO: clinical researches showed that, the output of urinary calcium and hydroxyproline in patients with PMO decreased, and the serum interleukin-6 as well as the tumor necrosis factor-α were reduced after treated by fructus psoraleae compound preparation. Symptoms of renal deficiency such as pain in lumbar vertebrae, sour tibia and powerless knee, talagia, tinnitus, deafness, lapsus pilorum and luxated tooth etc. The levels of serum estrogenic hormone and pregnancy hormone in patients were enhanced. The bone density in patients with PMO of liver and kidney deficiency was significantly increased, and the levels of T leukomonocyte subgroup CD3, CD4, the ratio of CD4/CD8 and levels of serum immune IgG, IgM were greatly enhanced in patients. Basic research suggested that: Bushen migu liquid (composed of equal amount of eucommia bark, walnut meat, fructus psoraleae, aceranthus sagittatus, adhesive rehmannia dried root and radix achyranthis bidentatae) could increase the contents of Ca, Mg, Mn, Cu in tibia of posterior limb in rats. Gukangfang extraction (composed of fructus psoraleae, aceranthus sagittatus, astragali radix, caulis cistanchis and danshen root etc.) could effectively enhance the in vivo content of dihydroxyestrin in demasculinized rats as well as enhance the bone gla protein content. ② The prevention and treatment effect of single fructus psoraleae: The fructus psoraleae could significantly promote the osteoblastic proliferation of new born rats, which indicated that the anti-effect of fructus psoraleae on osteoporosis was related to the osteoblastic number and its promotion effect on the reproductive activity of osteoporosis. CONCLUSION: ① Fructus psoraleae has certain clinical and experimental effect on PMO. ② Possible mechanism of action: hormonelike effect, can indirectly promote the proliferation of osteoblast and has significant inhibition effect on osteoclast. There are abundant manganese and zinc in fructus psoraleae, which can maintain the balance of microelements in the internal environment in vivo, promote the bone formation, ameliorate the molecular structure of bone matrix and reinforce the features in mechanics of bone organization.
【Fund】: 江苏省农机基金资助(GXZ05031)~~
【CateGory Index】: R285.5
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