Effect of Bcl-2 protein family and p53 gene on regulating and controlling cell apoptosis
Zhou J, Luo RB, Tang CF, Qu SL. 1Department of Human Science and Kinesiology, Institute of Physical Education, Hunan Normal University, Changsha 410012, Hunan Province, China; 2Xiangnan College, Chenzhou 423000, Hunan Province, China
OBJECTIVE: Cell apoptosis is the capacity of cells to undergo programmed cell death, which is controlled by a series of genes in the ontogeny course. Among most cell types, original cancer albumen Bcl-2 protein family and p53 gene are important factors to the apoptosis, connecting and interacting with each other in the apoptosis to regulate the apoptosis. In this review, to control and regulate the mechanism of Bcl-2 protein family and p53 gene on cell apoptosis. DATA SOURCES: A computer-based online search of related articles between 1995 and 2006 was conducted in Pubmed and Springer link by inputting the key words of "apoptosis, Bcl-2 protein family, p53", and the language was limited to English. Meanwhile, relevant Chinese articles between 1995 and 2006 were also searched in China Journal Full-text Database (CJFD) and Wanfang database with the key words in Chinese. Basis for Cell Apoptosis and Clinical Application was manually looked for. STUDY SELECTION: Data were checked in the first trial with the inclusion criteria of below: ① Relationship between Bcl-2 and apoptosis. ② Relationship between p53 and apoptosis. ③ Researches on cell apoptosis and gene regulation. ④ Study on the mechanism of Bcl-2 family and p53 gene regulation in cell apoptosis. DATA EXTRACTION: A total of 70 relevant literatures were collected. Chinese literatures were full texts, and most of foreign literatures were full texts, and others were abstracts. Thirty-two enrolled relevant articles were about the relationship and mechanism of Bcl-2 protein family, p53 gene and apoptosis as well as gene regulation of cell apoptosis. DATA SYNTHESIS: ① Bcl-2 protein family is the most common protein in researches on relevant gene of cell apoptosis, including two kinds of protein with contradictory effects on cell apoptosis. Bcl-2 protein family and its family members construct a complicated interacting net to regulate cell apoptosis. The regulative mechanism on cell apoptosis might be related to Bcl-2 protein family and mitochondria, the reciprocity among Bcl-2 protein family and Ca2+ and oxygen free radical. ② p53 gene is important for cell proliferation and impairing DNA gene groups. p53 gene regulation on cell apoptosis includes regulation on exogenous apoptosis and endogenous apoptosis. How do p53 gene regulate cell apoptosis on earth? Different experiments get different results due to different genetics background and microenvironment. ③ At present, there are three main methods in research on the regulation of p53 gene in the apoptosis. First, to distinguish DNA fragment and activate the genes activated by p53. Secondly,to distinguish genome or DNA groups activated by p53. Thirdly, to distinguish the basic apoptosis gene activated by p53. CONCLUSION: Many apoptosis gene are activated by p53. I focus on the control and regulative mechanism of Bcl-2 protein family and p53 gene to the apoptosis, and it may open up new vistas of research for cancer and angiocardiopathy.
【CateGory Index】： R341