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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2007-21
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Qingkailing versus ribovirin for children respiratory syncytial virus pneumonia:A single blinded,randomized,parallel control experiment

Liang JW,Yan HM,Yang Y,Ren XZ,Yuan B,Wang SC. 1Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu Province,China; 2Beijing Children Hospital,Capital Medical University,Beijing 100045,China  
AIM: To compare the therapeutic efficacy difference of Qingkailing and Ribavirin on respiratory syncytial virus pneumonia. METHODS: Totally 97 cases of children respiratory syncytial virus pneumonia were selected in Beijing children's hospital from February 2005 to April 2006,and their legal guardian knew the fact and consented. Adopting single blinded,randomized,parallel control experiment,children were divided into 2 groups by block randomization method: Qingkailing injection group (n =49) and Ribavirin group (n =48). ①Qingkailing injection group: The patients were treated with Qingkailing injection by intravenous drip and Chinese formulated products. ②Ribavirin group: The patients were treated with Ribavirin injection by intravenous drip and Compound guaiacol potassium sulfonale oral solution. The course of therapy was 10 days for each group. Curative effect of the two groups was compared. RESULTS: There were 3 amotic cases in Qingkailing injection group and 1 amotic case in ribovirin group. Totally 46 cases in the Qingkailing injection group and 47 cases in the ribovirin group were involved in the result analysis. ①The time for body temperature recovery from pyrexia was shorter in Qingkailing injection group as compared with ribovirin group (2.72±1.86) d,(6.29±2.41) d(P 0.01) . ②The amelioration of symptom integration for cough,phlegm blockage,accelerated breathing in Qingkailing injection group more surpassed than that in ribovirin group (P 0.05-0.01). ③The time of respiratory syncytial virus darkening in the Qingkailing injection group was markedly better than that in the ribovirin group. ④Cough,phlegm blockage,the time for respiratory syncytial virus darkening and accelerated breathing were all entering Logistic model. The modulus for the first two symptomatic regression coefficient was bigger. CONCLUSION: Qingkailing injection has obviously ascendence for children respiratory syncytial virus pneumonia in pyretolysis,relieving cough and asthma,the time for respiratory syncytial virus darkening. The cough and phlegm blockage can reflect the better therapeutic effect in Qingkailing injection and ribovirin.
【Fund】: “十五”国家科技攻关计划项目(2004BA716B03)《中医药治疗病毒性肺炎疗效评价方法研究》~~
【CateGory Index】: R725.6
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