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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2007-29
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Essentials of verifying immune inflammatory reaction in asthmatic animals

Liu SZ,Liu YL,Cao GL,Fang XB.1Hebei Tangshan Worker Hospital,Tangshan 063000,Hebei Province,China;2Department of Neurobiology,China Medical University,Shenyang 110001,Liaoning Province,China  
AIM:To understand the essences of generation and verification for immune inflammatory reaction in asthmatic models in order to perform further successful experiment.METHODS:An experiential summary on animal choice,time and preparation of model establishment as well as evaluation of successful models were carried out.Typical identification on asthmatic models at home and abroad was explained.RESULTS:①Asthmatic attack symptom could be fully observed in guinea pig models.Reaction level of guinea pigs was stronger than that of other animals after sensitizing and type Ⅰ allergy could be found.②Preparation of asthmatic models should not be in winter,and it is better in spring or summer.Inflammatory reaction of prepared asthmatic models was obvious.③It is scientific to stimulate asthma by 1% egg albumin atomizing inhalation.④Asthmatic symptom,pulmonary function detected by pulmonary function meter,histological change by haematoxylin-eosin staining,serum IgE level by enzyme-linked immunosorbent assay were used to analyze quantitatively asthmatic immune inflammatory reaction.CONCLUSION:It is the essences to make sure a successful trial by selecting proper animal,perfect sensitized time,and formulating stable method and good measurement.
【CateGory Index】: R562.25
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