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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2007-36
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Effect of blood-letting puncture at hand twelve Jing-acupoints on the behaviour,interleukin-1 beta and interleukin-6 in the plasma of depression rats

Miao Y,Ai Q,Cui XD 1Department of Traditional Chinese Medicine,Second Clinical College of Dalian Medical University,Dalian 116027,Liaoning Province,China; 2Social Security Office,Dalian Bureau of Finance,Dalian 116001,Liaoning Province,China  
AIM: To observe the antagonism against depression of blood-letting puncture at hand twelve Jing-acupoints in rats,and investigate the variations of plasma cytokines and behaviors. METHODS: From November 2005 to February 2006,this experiment was conducted cooperatively with the Animal Experimental Base of Dalian Medical University and the Central Laboratory of the Second Hospital Attached to Dalian Medical University.①Thirty-two adult wistar rats of common grade and half gender were used in this study,aged 180-220 g.②These rats were randomly allocated to four groups (n =8): normal control group,model group,fluoxetine group and blood-letting puncture group.③The rats of normal control group were fed routinely without stimulation and treatment. While other rats were singly housed and exposed to different stressors for 21 days,those of model group received no treatment,those of fluoxetine group were injected with 2.8 mg/kg drugs intragastrically,once per day,and those of puncture group were pricked on twelve Jing-acupoints of rat bilateral forelimb toes for blood-letting,one drop for one acupoint,once every two days,for totally 11 times.④The behavior index (by Open-Field method) and the levels of interleukin (IL)-1β,IL-6 in plasma of depression rats were compared,respectively. RESULTS: All of 32 rats were involved in the result analysis.①Compared with the model group,the levels of IL-1β and IL-6 in plasma of rats in normal control group,fluoxetine group and puncture group all had significant differences (P 0.01); There was no significant difference between puncture group,model group and control group,between puncture group and fluoxetine group (P 0.05).②Compared with the model group,the horizontal score and perpendicular score of control group had significant differences (P 0.01),these scores of puncture group and fluoxetine group also had significant differences (P 0.05-0.01); No significant difference was found between the puncture group and fluoxetine group (P 0.05). CONCLUSION: Blood-letting puncture at hand twelve Jing-acupoints can decrease the levels of IL-1β and IL-6 in plasma of depression rats and improve the behaviour,so as to have antagonism against depression.
【CateGory Index】: R245
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