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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2008-06
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Characteristics of controlled release drug carrier materials

Wang DanDepartment of Phar- macy, Seventh Peo- ple's Hospital of Shenyang, Shenyang 110003, Liaoning Province, China  
BACKGROUND: Drug-controlled release preparation by drugs or other active substances combined with carriers, has been an important development trend in field of pharmacy. However different characteristics of controlled release drug carrier materials leas to different drug release behaviors, so recent researches focus on a new type of drug carrier material to obtain the satisfactory drug release. OBJECTIVE: To introduce some drug carrier materials, and analyze those materials' characteristics and their application on drug controlled-release. RETRIEVAL STRATEGY: A computer-based search was undertaken on China Journal Full-text Database from January 1998 to June 2007, with the Keywords of "polymeric hydrogel, polylactic acid, chitosan, silk fibroin, drug controlled-release, drug carrier" and language was limited to Chinese. Inclusion criteria: ①preparations and characteristics of various drug carrier materials;②drug controlled release of various drug carrier materials. Exclusion criteria: outdated literatures. LITERATURE EVALUATION: Eighty-six related articles were screened out, and 28 of them met the criteria, including 10 were reviews and others were clinical or basic experiments. DATA SYNTHESIS: ① At present, the materials applied for drug carrier include polymeric hydrogel, polylactic acid/poly(lactic-co-glycolic acid), chitosan and their derivates, silk fibroin and so on.②Intellectual polymeric hydrogel can respond swelling and contraction for the stimulation of temperature, acidity, pressure and light, etc. And the specific environment sensitiveness enlarges its application in drug delivery system.③Polylactic acid and poly(lactic-co-glycolic acid), as a kind of biodegradable polymer materials, represent biocompatibility, biodegradability and non-toxic degradation products. As for controlled release drug carrier material, it can influence drug release by modulating degradation of polylactic acid, so as to increase drug efficacy.④Chitosan is satisfactory in adsorbability, film forming ability and permeability. Water-soluble chitosan with low relative molecular mass is prone to degrade and difficult to accumulate, so chitosan nanoparticles or chitosan microspheres as carriers for drug delivery system have been the hot topic of recent researches.⑤Native polymer material silk fibroin is non-toxic and non-stimulative, shows good physical, chemical and biological characteristics, as well as satisfactory histocompatibility. The pH value responsibility and zymohydrolysis are also observed when loading and releasing drugs. Chemical modification and addition of other compounds will increase the characteristics and the drug-controlled release of silk fibroin. CONCLUSION: Various drug carrier materials show good biocompatibility, biodegradability, physicochemical and biological stability, extremely low toxicity, and high drug loading property. But the material's performance should be synthesized and modified in practical application to satisfy various preparations of drug-controlled release by specific performance and structure.
【CateGory Index】: R318.08
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