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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2008-41
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Effects of Diclofenac Sodium Dual Release Capsules on proprioception of patients with knee osteoarthritis

Guo Ji-tao,Dai Qi-ping,Qiu Min-lei,Chen Yong-qiang Department of Orthopaedics,Shanghai Hospital of Traditional Chinese Medicine,Shanghai 200071,China  
BACKGROUND:The function of proprioception is defective in patients with knee osteoarthritis.The proprioception plays an important role in preventing knee degenerative disease.OBJECTIVE:To observe the effect of Diclofenac Sodium Dual Release Capsules,a non-steroid antiinflammatory drug,on proprioception of patients with knee osteoarthritis.DESIGN,TIME AND SETTING:One sample self-contrast research was performed at the Department of Orthopaedics,Shanghai Hospital of Traditional Chinese Medicine between June 2007 and March 2008.PARTICIPANTS:Twenty-eight outpatients with knee osteoarthritis were selected from the Department of Orthopaedics,Shanghai Hospital of Traditional Chinese Medicine.METHODS:The twenty-eight patients orally took one capsule for each time,once a day for 4 continuous weeks.By means of self-control,the change of the joint position sense and joint motion sense of one affected knee joint were observed.MAIN OUTCOME MEASURES:Before and 4 weeks after treatment,changes of joint position sense(passive angle reproduction and active angle reproduction)and joint motion sense(threshold to detection of passive movement)were measured by Biodex System3.RESULTS:Of the 28 affected joints,the average values of joint position sense(passive angle reproduction and active angle reproduction)had no significant differences between before and after treatment(P 0.05),but for patients with mild disease,active angle reproduction 10°,the values of passive angle reproduction and active angle reproduction were significantly lower than before treatment(P 0.05).After 4 weeks of treatment,the threshold to detection of passive movement was significantly lower than before treatment(P 0.05).CONCLUSION:Sodium Dual Release Capsules can significantly improve joint motion sense and slight defect joint position sense of patients with knee osteoarthritis.
【Fund】: “针灸对膝关节骨关节炎本体感觉影响的临床研究”:上海市重点学科建设项目(T0303)~~
【CateGory Index】: R684
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