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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2009-25
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Preparation and in vitro percutaneous permeation profile of matrine ethosomes

Liu Xing-yan, Liu Hong, Zhang Yang-de, Zeng Zhao-wu, He Jian-taiNational Hepatobiliary & Enteric Surgery Research Center, Ministry of Health, Central South University, Institute of Biomedical Engineering of Central South University, Changsha 410008, Hunan Province, China  
BACKGROUND: Ethosome is a new liposome with high deformability, high entrapment efficiency and permeating completely through skin. It is especially suitable for the carrier of external administration and cutaneous penetration. OBJECTIVE: To prepare matrine ethosomes and evaluate the percutaneous permeation profile in vitro on rat’s skin. DESIGN, TIME AND SETTING: A comparison observation experiment was performed in the Laboratory of National Hepatobiliary Enteric Surgery Research Center, Central South University from August 2007 to March 2008. MATERIALS: Raw material of matrine was produced by Xi’an Huapeng Natural Production Co., Ltd. Soybean lecithin was the production of American Avanti Polar Lipids Inc. METHODS: Matrine ethosomes comprised 10–30 g/L of lecithin, 30%–45% (v/v) ethanol, 10 g/L matrine and water, which were prepared by ethonal infusion and ultrasonic method. The percutaneous permeation of matrine ethosomes was evaluated with a Franz diffusion cell, matrine concentration was detected by HPLC from the examples of a receiving cell after administration at a supplying cell. MAIN OUTCOME MEASURES: The size entrapment efficiency and erythema index variation in vitro on rats of matrine ethosomes. RESULTS: The mean size of matrine ethosomes decreases with increasing ethanol concentrations whereas it increases as phospholipid concentrations increase, and the entrapment efficacy increases with increasing ethanol and phospholipids concentrations. The matrine ethosomes showed a permeation profile with a maximal cumulative amount of matrine permeated after 24 hours of 60.5% of the applied dose, and no lag time. CONCLUSION: The matrine ethosomes were successfully prepared, which showed an increase of the percutaneous permeation of matrine in vitro.
【CateGory Index】: TQ461
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