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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2009-46
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Chromosome analysis technique and its significance

Zhang Ga1,2,Li Lin-feng2,3,Narentunala1,2,Hasisurong1,Guan Wei-jun2 1College of Animal Science and Medi-cine,Inner Mongolia Agricultural Univer-sity,Hohhot 010018,Inner Mon-golia Autonomous Region,China;2Animal Husbandry and Veterinary Research Institute,Chinese Academy of Agricultural Science,Beijing 100193,China;3Shanxi Agricultural Univer-sity,Taigu 030801,Shanxi Province,China  
The chromosome is the carrier of genetic materials.It stores and transmits DNA,controls gene activity and regulates gene reorganization function.The researches on chromosome shape,structure,and banding pattern are foundation of gene mapping research.Conventional cytogenetics detection is regarded as accurate evidence for survival grafts following heterogenous hemopoietic stem cell transplantation;periodical chromosome examination can dynamically monitor status following hemopoietic stem cell transplantation,and judge the cause of leukemia recrudescence.The selective chromosome as genetic marker of minimal residual disease is significant to predict relapse following transplantation at chimerism condition.This article introduced the karyotype analysis technique of chromosome,chromosome banding technique,and in situ chromosomal hybridization,aiming to lay a foundation for studies on cell transplantation and chromosome.
【Fund】: 国家自然科技平台建设项目(2005DKA21101);; 2006年国家自然科学基金项目(30671539)~~
【CateGory Index】: R394
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