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《Journal of Clinical Rehabilitative Tissue Engineering Research》 2010-51
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Intra-articular injection of polylactic acid microspheres containing compound Chinese herbal medicine into rabbits with knee osteoarthritis

Zhao Hong-pu1,Xu Qiu-yu2,Yang Fan3 1Department of Orthopaedic Surgery,Third Affiliated Hospital of Guangzhou Medical Collage,Guangzhou 510150,Guangdong Province,China;2Department of Outpatient,First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China;3Department of Pharmacy,Guangdong College of Pharmacy,Guangzhou 510224,Guangdong Province,China  
BACKGROUND:Guyan Yihao is composed by epimedium,psoralen and angelica.It has effects on invigorating liver and tonifying kidney,strengthening the muscles and bones,promoting blood circulation by removing blood stasis,removing obstruction in the channels to relieve pain.OBJECTIVE:To explore the availability of intra-articular injection of Guyan Yihao microspheres on the osteoarthritis of rabbit's knee.METHODS:New Zealand white rabbits were divided randomly into normal saline-treated group,sodium hyaluronate-treated group,and Guyan Yihao polylactide microsphere-treated group.All of their right knees were made osteoarthritis model with Hulth method.At 6 weeks after operating,the animals were injected respectively with normal saline,sodium hyaluronate,and Guyan Yihao polylactide microspheres into the right knee once a week for 5 times.Two weeks after the last injection,the animals were sacrificed and the affected knee joints were harvested for gross anatomical and histomorphological evaluation.RESULTS AND CONCLUSION:In Guyan Yihao polylactide microsphere-treated group and sodium hyaluronate-treated group,the arthritis index was decreased significantly compared with saline-treated group (P0.05),and articular cartilage cataplasia was relieved.There were no significant differences between Guyan Yihao polylactide microsphere and sodium hyaluronate,but Guyan Yihao was less effective than sodium hyaluronate.Guyan Yihao polylactide microspheres are available in intra-articular injection for osteoarthritis treatment.Some protective effects of Guyan Yihao on arthritis is showed in this study.
【Fund】: 广东省中医药局项目(103006);; 广东省卫生科技基金项目(A2008289);; 广东省科技计划项目(粤科函社字[2010]1096号)~~
【CateGory Index】: R285.5
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