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《Chinese Journal of Tissue Engineering Research》 2014-02
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The association between angiotensin converting enzyme gene polymorphism and Alzheimer's disease in Jiamusi region

Zhang Shu-ping;Xuan Zhao-bo;Huang Zuo-yi;Liu Ying-qin;Liu Qing;Wang Xiang-yu;Wu Cheng-ji;Yang Li-min;Zeeshan Abbas;Neurology Department of the First Hospital Affiliated to Jiamusi University;Department of Heredity,Jiamusi University;University of Lahore;  
BACKGROUND: Angiotensin-converting enzyme as a key enzyme of the renin-angiotensin system, through the degradation effects of substance P mechanism, is involved in the occurrence and development of Alzheimer's disease. OBJECTIVE: To research the relationship between angiotensin-converting enzyme gene polymorphism and Alzheimer's disease in Jiamusi region, as well as the effect of gender and hypertension on the relationship. METHODS: This case-control study included 96 Alzheimer's disease patients. Another 102 subjects served as controls coming from the same area and in the same environmental condition. DNA segments were amplified using PCR in 20 g/L agarose gel electrophoresis and observed under ultraviolet lamp. II, ID, DD genotypes and genotype frequencies were calculated for statistical analysis. On this basis, according to clinical data collected, we investigated association of Alzheimer's disease with hypertension and gender. RESULTS AND CONCLUSION: There was significant difference between Alzheimer's disease patients and controls in angiotensin-converting enzyme genotypes and allele frequency. There was statistically significant difference between Alzheimer's patients with hypertension and controls in angiotensin-converting enzyme genotypes and allele frequency. There was no statistical difference between Alzheimer's disease patients with different genders and controls in angiotensin-converting enzyme genotypes and allele frequency. These findings indicate that there are somerelationships between angiotensin-converting enzyme polymorphism and Alzheimer's disease. II genotype is a risk factor for Alzheimer's disease, angiotensin-converting enzyme II genotype is a risk factor for Alzheimer's disease with hypertension.
【Fund】: 黑龙江省自然科学基金项目(C201242);; 黑龙江省教育厅基金面上项目(12511562)~~
【CateGory Index】: R749.16
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