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《Journal of Modern Stomatology》 2007-03
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Expression of vascular cell adhesion molecule-1 and its relationship with cancer angiogenesis in oral squamous cell carcinoma

SUN Legang,LIU Ling,FENG Hongchao,et al. Department of Oral and Maxillofacial Surgery,The Affiliated Hospital of Binzhou Medical College,Binzhou 256603  
Objective To detect the expression of vascular cell adhesion molecule-1(VCAM-1)in oral squamous cell carcinoma(OSCC),and explore its relationship with the microvessel density in OSCC.Methods Expression of VCAM-1 and CD31 in 48 cases of OSCC and 10 cases of normal oral mucosa was detected by immunohistochemistry.Microvessel density was assessed based on the expression of CD31.Results VCAM-1 was expressed not only in the squamous cancer cell but also in vascular endothelial cells.VCAM-1 was detectable in 31 out of 48(64.58%)cases of OSCC and none in 10(0.00%)cases of normal oral mucosa(P0.01).Microvessel density was higher in OSCC than in normal oral mucosa and was related to lymph node metastasis and infiltration depth.Microvessel density was significantly higher in VCAM-1-postive OSCC than in VCAM-1-negative OSCC(P0.01),and also positively correlated with the expression of VCAM-1(P0.01).Conclusion Over-expression of VCAM-1 in OSCC may be closely correlated with cancer angiogenesis.
【Fund】: 贵州省第二批跨世纪人才省政府专项基金资助(黔科合人专字2000-9813号);; 贵州省优秀科技教育人才省长专项基金资助(黔科教办[2004]07号)
【CateGory Index】: R739.8
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2 LIANG Dapeng1 PAN Xinliang1 SUN Wenhai2 HUANG Yichuan2 (1Department of Otolaryngology Head and Neck Surgery,Qilu Hospital of Shandong University,Jinan,250012,China;2Department of Otolaryngology Head and Neck Surgery,the Affiliated Hospital of Medical College,Qingdao University);The expression and relationship of vascular cell adhesion molecule-1 and P-selectin and microvessel density in hypopharyngeal carcinoma[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2009-03
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1 Feng Hong-Chao1, Song Yu-Feng1, Wen Yu-Ming21.Department of Oral and Maxillary Surgery,The Affiliated Hospital of Guiyang Medical College, Guiyang,Guizhou,550004, P.R.China 2.Department of Oral and Maxillary Surgery,West China University of Medical Science, Chengdu,Sichuan,610041, P.R.China;Correlation between Expression of Vascular Endothelial Growth Factor-C in Tumor-associated Macrophages and Lymphatic Metastasis in Oral Cancer[J];Chinese Journal of Cancer;2004-03
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3 SONG Yu-feng, LI Chao, FENG Hong-chao (Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China);A Preliminary Study on the Expression of Angiopoietin-2 in Oral Squamous Cell Carcinoma[J];Journal of Guiyang Medical College;2005-03
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