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《Journal of Modern Clinical Medical Bioengineering》 2002-05
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~(125)I Seed Permanent Implanting(Brachytherapy) Combined with Transperineal Interstial Radiofrequency for the Treatment of Prostate Cancer

CHEN Guang-chun,WU Kai-jun  
Objective To assess the effectiveness of 125I brachytherapy with interstitial radiofrequency in prostate cancer. Methods From 2001/7 to 2002/6,12 patients with prostate cancer diagnosed by pathologic examination ,were treated with 125I seed implants combined with transperineal interstitial radiofrequency under transrectal ultrasound guidance. Results It was no side effects on liver or kidney function damage. Seven cases had a slight increase in urinary frequency,urgency and nocturia with 1 moths after treatment.IPSS and volume of prostate increased but not significant at 1 monlhs after treatment(p0.05).One case occurred dysuria at 3 days after therapy when removed the catheter.PSA decreased significantly at 1,3,6,months after therapy compared with preoperation(p0.05) IPSS and volume of prostate also decreased significantly compared with pretreatment at 3,6 months after therapy. Conclusion 125I seed permanent implanting (brachytherapy) combined with transperineal interstial radiofrequency for the treatment of prostate cancer was effective and feasible in short period ,the amounts of seeds implanting reduced obviously with the combination of two individual treatment modalities than brachytherapy alone,the long-term effects should be assessed further.
【CateGory Index】: R737.25
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