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《Chinese Journal of Modern Operative Surgery》 2009-05
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Effect of the Mild Hypothermia on the Cerebral Vasospasm after Severe Traumatic Brain Injury Operation

XIA Yong-qin,YAN Li-li,LIU Shao-ming,XU Ru-xiang,WANG Xiang-yu(Department of Neurosurgery,Urumqi General Hospital of Lanzhou Military Region of PLA,Urumqi 830000,Xinjiang,China)  
Objective To investigate the effect of mild hypothermia on cerebral vasospasm after severe traumatic brain injury(sTBI) operation and its future prognosis.Methods Thirty-six patients with sTBI(GCS≤8) were randomly divided into the conventional therapy group(control group) and the mild hypothermia group with 18 patients in each.The cerebrovascular hemodynamic indices(CVDI) were measured 0,1,3,7,10,14,21 days after sTBI with the cerebrovascular hemodynamics analyzer.Results Compared with normal group,posttraumatic CVDI in the control group was divided into 4 phases: hypoperfusion(Day 0),hyperperfusion(Days 1~3),cerebral vasospasm(CVS)(Days 4~14),intermediary(15 days).There were three phases in the mild hypothermia therapeutic group:hypoperfusion(Day 0),intermediary(Days 1~3),recovery(4 days).There were 8 cases and 2 cases of CVS in the control and the therapy group respectively(P 0.05).At 3 months follow-up,the rates of unfavorable prognosis were 61.1%(11/18) in control group and 33.3%(6/18) in the mild hypothermia group(P0.05).After 3 years follow-up,the rates of unfavorable prognosis were 55.6%(10/18) in control group and 22.2%(4/18) in the mild hypothermia group(P0.05).Conclusions Preventing and curing of CVS is important after sTBI operation.Mild hypothermia treatment can reduce the incidence of CVS by stabilizing cerebral circulation after sTBI,so that the future prognosis can be improved.
【Fund】: 中国人民解放军兰州军区医药卫生科研基金资助项目(LHX-2007010);; 全军临床医学中青年人才培养基金资助项目
【CateGory Index】: R651.15
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