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《Chinese Journal of Modern Applied Pharmacy》 1989-03
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A Comparison on the Protecetive Action Against Liver Lesions of Total Saponins of Gynostemma Pentaphyllum and Oleanolic Acid

Xu Shenglin (Hangchow Pharmaceutical Institute)  
Total saponins of Gynostemma Pentaphyllum and Oleanolic acid were found to be effective in the protection of experimental acute liver injury induced by injection of CCl_4 in rats.The results of this investigation indicate that the SGPT level with CCl_4 were markedly decreased, The degeneration and necrosis of liver cells were also significantly diminished by teratment with 50mg/kg of total saponins of Gynostemma Pentaphyllum.The regeneration of liver cells was effectively promoted by treatment with total saponins of Gynostemma Pentaphyllum and Oleanolic acid.Both have the similar effect.
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