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《Chinese Journal of Modern Applied Pharmacy》 1993-01
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Effect of Anisodamine on the fluidity of erythroyte membrane and the intrinsic fluorescence of ghost

Yan Goudong Zhou Wenhua,et al.(Ningbo microcirculation & herb drugs institute,Ningbo 315010)  
Anisodamine(Ani)could increase significantly the intact erythrocyte membrane fluidity in the presence or absence of CaCl_2.The intrinsic fluorecence of erythrocyte ghost was depressed by Ani in a dose-dependent manner.In the presence of 2 mmol/L CaCl_2 and Ani at 1 mmol/L in the medium,the rate of quenching of intrinsic fluorescence was higher than that of ghost treated by CaCl_2 or Ani alone.These data indicate that Ani has an effect on the hydrophobic region of the membrane,and causes the energy transfer by interacting directly with the membrane protein.
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