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《CHINESE JOURNAL OF MODERN APPLIED PHARMACY》 1999-02
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Effects of haloperidol on immune regulations of melatonin in mice

Yang Yingbao(Yang YB),Luo Jinghui(Luo JH),Yang Shuqin(Yang SQ),et al(First Military Medical University,Guangzhou 510515)  
OBJECTIVE:To study the effects of haloperidol(Hal) on immune regulation of melatonin(MT) in mice.METHODS:Mice were housed in a standardized light-dark cycle with food and water for a week before experiment.The lymphocyte percentage(Lym%),T-lymphocyte percentage(T-Lym%) and serum hemolysis formation(HC 50 value) in peripheral blood of mice were determined,respectively.RESULTS:MT(20μg/kg) significantly enhanced Lym%,T-Lym% and HC 50 value.Hal(0.4~1.6mg/kg) had no direct influence on Lym%,T-Lym% and HC 50 value,but completely depressed the effective immune enhancement of MT.CONCLUSION:One of mechanisms of MT immune enhancement may be the intermediation of dopamine receptor.
【CateGory Index】: R96
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