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《CHINESE JOURNAL OF MODERN APPLIED PHARMACY》 1999-03
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Effects of puerarin on plasma endothelin and nitric oxide in patients with essential hypertension

Huang Zhaoquan(Huang ZQ),Ye Wu(Ye W),Chen Shejie(Chen SJ),et al(Zhejiang Provincial Traditional Chinese Medicine Hospital,Hangzhou 310006)  
OBJECTIVE:To evaluate the alteration of plasma Endothelin(ET)and Nitric Oxide(NO)in patients with Essential Hypertension(EH),and the involvement of treatment with puerarin.METHODS:Two different treatments were set up as follows:P.0.5mg amlodipine or/and 10mg benazepril(AML or/and BEN),AML or/and BEN combinated with iv gtt 400mg puerarin in 250ml 5% GNS,qd,every 15 days was taken as a treatment course.The alteration of plasma ET and NO was measured before and after the treatments,and the differences between the two groups were compared.RESULTS:Compared with the health control group,the plasma ET of the EH in each group was significantly higher(P0.05,P 0.01 ),while the levels of plasma NO and the NO/ET ratio were markedly lower except those in mild EH group(P0.01),The levels of plasma ET and NO as well as NO/ET ratio were positively or negatively correlated with diastolic blood pressure,respectively(r=0.955,r=-0.931,r=-0.973).There were markedly differences of plasma ET and NO between the two groups(P0.05),as well as before and after treatment of AML or/and BEN combinated with puerarin,respectively(P0.01,P0.05).CONCLUSION:The increased Plasma ET or decreased Plasma NO were well correlated with EH.Puerarin could adjust the levels of plasma ET and NO companying down-adjusting blood pressure effect.
【Fund】: 浙江省中医药管理局科研基金资助项目!98B17
【CateGory Index】: R544.1
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