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《CHINESE JOURNAL OF MODERN APPLIED PHARMACY》 2000-05
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The study of Lentinan to increase antitumor activity and secretion of cytokines of tumor infiltrating lymphocytes

Li Guangzhou(Li GZ),Kang Bai(Kang B),Guo Baoqiang(Guo BQ)(Department of Nuclear Medicine,Affiliated Hospital of Weifang Medical College,Weifang 261031)  
OBJECTIVE:To study the influences of Lentinan on antitumor activity and secretion of cytokines of tumor infiltrating lymphocytes(TIL).METHOD:TIL isolated from patients with lung carcer was cultured in IL 2 or IL 2 combined with Lentinan for 30 days,respectively.Antitumor activity and production of TNF α,INF γ of TIL were observed.RESULTS:After 25 days,antitumor activity and production of TNF α,INF γ of TIL cultured in IL 2 combined with Lentinan were higher than that of TIL cultured in IL 2(P0.05).CONCLUSION:Lentinan has an increasing action on antitumor activity and secretion of cytokines of TIL.
【CateGory Index】: R285
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