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《The Chinese Journal of Modern Applied Pharmacy》 2004-02
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The therapeutic effects of various anthraqyinones in Rhizoma Polygoni Cuspidati on HSV-1 cutaneous infection in guinea pigs

WANG Zhi-jie 1,HUANG Tie-niu 2(1.Virus Research Institute,College of Wuhan University,Wuhan 430071,China.2.Zhongnan University of Economics and Law,Wuhan 430064,China)  
OBJECTIVE In order to investigate antiherpes effects of various anthraquinones in Rhizoma Polygoni Cuspidati on human simplex virus type-1 in vivo. METHOD Guniea pigs infected with cutaneous herpes virus were applied to study the effects of crystal-Ⅰ, Ⅱ, Ⅲ and Ⅳ from Rhizoma Polygoni Cuspidati. Acyclovir (ACV) was used as positive control, while PBS and PBS containing 0.1% Tween-80 were used as negative controls.RESULTS The cumulative scores of the regions dealt with ACV, crystal-Ⅰ, Ⅱ, Ⅲ and Ⅳ were 14.20 ±6.70, 7.00 ±6.16, 7.31 ±6.16, 11.63±6.07 and 8.50 ±4.63, respectively. The healing days of the regions were 7.70 ±1.08, 6.30±1.40, 6.50± 1.10, 8.20±0.67 and 6.80±1.35, respectively, which had significant difference with those of the negative controls. The same results were obtained from the pictures and measurements of virus titers of skin samples of each treatment region. CONCLUSION The results of Student's t test suggested that the cumulative scores and healing days of skin regions dealt with ACV had significant differences in statistics with the cumulative scores and healing days of skin regions dealt with crystal I,-II.These results together with the results of measurements of virus titre suggest the antiherpes effects of crystal I,-II are better than ACV.It is worthwhile to develop crystal Ⅰ and Ⅱ.
【Fund】: 湖北省自然科学基金资助
【CateGory Index】: R285
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Wang Zhijie(Wang ZJ),Fang Xieyun(Fang XY),Chen Zhongmian(Chen ZM)(Department of Oncogenic Virus,Virus Research Institute,Hubei Medical University,Wuhan 430071);Research about antiviral effect of ethyl acetate component of Rhizoma polygoni cuspidati on herpes virus hominis[J];CHINESE JOURNAL OF MODERN APPLIED PHARMACY;1999-05
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 SUN Ju-feng Department of General Medicine,Binzhou Medical College;Antiviral Active Ingredients in Plants[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2007-03
2 ZHENG Shan-zi,SHEN Cheng-hua,PIAO Hua-zi(College of Basic Medicine,Yanbian University,Yanji 133000,China);Effect of Pulse-activating Powder Combined with the Roast Glycyrrhiza Decoction on Cultured Rat Myocardial Cells Infected with Coxsackie Virus B_3[J];Lishizhen Medicine and Materia Medica Research;2007-06
3 SHEN Cheng-hua,ZHENG Shan-zi,CUI Chun-quan,et al(The Medical College of Yanbian University,Yanji 133000);EXPERIMENTAL STUDY ON PROTECTIVE EFFECTS OF POLYGONUM CUSPIDATUM WATEREXACT ON RATS' CARDIAC MUSCLE CELL INFECTED BY COXSACKIE VIRUS B_3 IN VITRO[J];Chinese Journal of Traditional Medical Science and Technology;2005-01
4 ZHENG Min,MEI Xian-chen, BAO Cui-yu,WU Ji-liang, LI Li-zhong, CHENG Hong-guang(Department of Pharmacology , Xianning College ,Xianning, 437100,China);Effect of polysaccharide from Allium sativum L. on coxsackievirus group B type 3 in vitro[J];The Chinese Journal of Modern Applied Pharmacy;2005-01
5 Meng Qian, Jiang Aibo, Liu Yanwen, et al (Hubei College of TCM, Wuhan 430061);Study on Anti- HSV-Ⅱ Function of Compound Alternanthera Philoxeroides (Mart .) Griseb[J];Chinese Journal of Information on TCM;2002-12
6 WANG Zhi jie 1,HUANG Tie niu 2,LIU Yan wen 3 (1.Virus Research Institute of Medical College of Wuhan University, Hubei Wuhan 430071, China; 2.Zhongnan University of Economics and Law,Hubei Wuhan 430064,China; 3.Departement of Chinese Materia Medi;The Effect Analysis of Antiherpes Simplex Virus Type-2 333 Strain with Combination of Emodin of Rhizoma Polygoni Cuspidati and Total Polysaccharides in The Root of Astragalus Membranacues[J];China Journal of Basic Medicine In Traditional Chinese Medicine;2002-05
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 CHEN Lei1, YANG Fu _ quan2, ZHANG Tian _ you2, HAN Ya _ shan1, CHEN Shang _ wu1(1. China Agricultural University, Beijing 100094, China;2. Beijing Institute of New Technology Application, Beijing 100035, China);Separation and Analysis of Resveratrol and Piceid in Polygonum Cuspidatum Sieb. et Zicc.[J];JOURNAL OF INSTRUMENTAL ANALYSIS;2000-04
2 Wang Zhijie(Wang ZJ),Fang Xieyun(Fang XY),Chen Zhongmian(Chen ZM)(Department of Oncogenic Virus,Virus Research Institute,Hubei Medical University,Wuhan 430071);Research about antiviral effect of ethyl acetate component of Rhizoma polygoni cuspidati on herpes virus hominis[J];CHINESE JOURNAL OF MODERN APPLIED PHARMACY;1999-05
3 Wang Zhijie, Huang Tieniu 1, Liu Yanwen 2, Lu Suiyong, Yang Zhanqiou, Fang Xueyun((1. Medical College of Wuhan University,Wuhan430071,Zhongnan University of Economics and Law,Hubei,China.2.Department of Chinese Material Medica,College of Traditional Chi;The experimental research of antiherpes simplex virus effects of various components in the root of Astragalus membranaceus[J];Chinese Journal of Modern Applied Pharmacy;2002-05
4 WANG Zhi jie 1,HUANG Tie niu 2(1.Virus Research Institute, College of Wuhan University, Wuhan 430071, China;2.Zhongnan University of Economic and Law, Wuhan 430064, China);The therapeutic effects on human simplex virus cutaneous infection of guniea pigs of various components in the root of Astragalus membranaceus[J];The Chinese Journal of Modern Applied Pharmacy;2003-06
5 Wang Zhijie,Cheng Zhongmin and Fang Xieyun (Department of Oncogenic Virus, Virus Research Institute, Hubei Medical University, Wuhan 430071);Antiviral Action of Combined Use of Rhizoma Polygoni Cuspidati and Radix Astragali on HSV 1 F Strain[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1999-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Chen Fuxiang; Liu Jingxing; Lu Deyuan(Department of Microbiology, Shanghai Second Medical University, 200025);The Effects of Sophora Flavescens Alkaloids (SFA) on Coxsackie Virus B3(CVB3)in Vitro and a Preliminary Study of Its Mechanism[J];CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY;1995-02
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