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《The Chinese Journal of Modern Applied Pharmacy》 2005-01
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Effect of polysaccharide from Allium sativum L. on coxsackievirus group B type 3 in vitro

ZHENG Min,MEI Xian-chen, BAO Cui-yu,WU Ji-liang, LI Li-zhong, CHENG Hong-guang(Department of Pharmacology , Xianning College ,Xianning, 437100,China)  
OBJECTIVE To invesigate the inhibitory effects of polysaccharide from Allium sativum L. on Coxsackievirus group B type 3(CVB_3)in vitro.METHOD The following experiments about polysaccharide from Allium sativum L. A , B and C were performed: the cytotoxicities test on Hep-2 cell, the direct inactivation of CVB_3,the inhibition of CVB_3 adsorption and biosynthesis.RESULTS The 50% toxic concentration (TC_ 50) of polysaccharide from Allium sativum L. A , B and C on Hep-2 cell were 1000,800 and 4000μg/mL respectively. The above three components showed no direct inactivation of CVB_3 or inhibition of CVB_3 virus adsorption. With the exception of polysaccharide from Allium sativum L. A, components B and C could dose-dependently inhibit CVB_3 biosynthesis. CONCLUSION polysaccharide from The Allium sativum L. B and C can produce obvious inhibitory effects on Coxsackievirus group B type 3(CVB_3) in vitro by prevention of CVB_3 biosynthesis.
【Fund】: 湖北省教育厅重点项目(2003A004)
【CateGory Index】: R285.5
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