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《The Chinese Journal of Modern Applied Pharmacy》 2005-02
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Preparation and CT contrast enhancement in animals of X-ray contrast agent Ioversol injection

LIU Ya-ling1,LUO Shi-neng1, ZOU Pei1,XIE Min-hao1, HE Yon g-jun1,WANG De-hang2, PAN Xi-jian2(1.Jiangsu Institu te of Nuclear Medicine, Wuxi 214063,China; 2.First affiliated Hospital of Nanji ng Medical University, Nanjing 210029,China)  
OBJECTIVE To prepare the non-ionic X-r ay contrast agent Ioversol injection and study its contrast effects in rabbits,the n compare its contrast enhancement with that of optiray, a imported identical va riety. METHOD Ioversol injection was prepared with our self-made iove rsol, tromethamine and edetate calcium disodium and the quality of the injection was detected according to USP 25. 5 New Zealand rabbits were intravenously anes thetized with 20% urethan (4mL/kg) and then each injected with ioversol injectio n and optiray through ear limbic vein intermittently in 2 days (1.5mL/kg, 1.5mL/ s). After each injection, contrast enhancement of livers and ventral aorta were observed and the effects of ioversol injection and optiray within a same animal were compared. RESULTS Contrast effects of our self-made ioversol injection w ere identical with those of optiray. There was no significant difference between them statistically. CONCLUSION Optiray could be replaced with our self-made iovers ol injection in CT.
【Fund】: 江苏省科技厅(BJ2000048);; 江苏省卫生厅(H9810)科研项目资助
【CateGory Index】: R943
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Chinese Journal Full-text Database 1 Hits
1 LUO Shi-neng,ZOU Pei,LIU Ya-ling,XIE Min-hao,HE Yong-jun, YANG Zheng (Jiangsu Institute of Nuclear Medicine , Wuxi 214063, China );Synthesis of ioversol,a non-ionic x-ray contrast agent[J];Chinese New Drugs Journal;2004-04
Chinese Journal Full-text Database 9 Hits
1 Tu Zhenzhu,Xie Changqin,Lu Manli Second Affiliated Hospital, Hubei Medical University,Wuhan 430071,China;The Adverse Effects and Rational Use of Contrast Media in the Enhanced CT Examination[J];JOURNAL OF HUBEI MEDICAL UNIVERSITY;2000-03
2 ZHANG Lai-guo 1,2,LUO Shi-neng *1,2,LIU Xiao-ya1,XIE Min-hao2,ZOU Pei2,LIU Ya-ling2,HE Yong-jun2 (1.School of Chemical and Material Engineering,South Yangtze University,Wuxi 214036,China;2.Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China);The synthesis of N,N′-bismethyl-N,N′-bis-(2,3,4,5,6-pentahydroxyhexyl)-2,3,5,6-tetraiodoterephthalamide[J];Chemical Reagents;2006-07
3 ZOU Pei,LIU Ya-ling,XIE Min-hao,LUO Shi-neng,HE Yong-jun,WU Jun,WANG Hong-yong (Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China);Synthesis of 5-amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid[J];Chemical Reagents;2007-08
4 ZHANG Lai-guo1,2,LUO Shi-neng2,1*,XIE Min-hao2,LIU Xiao-ya1,ZOU Pei2,LIU Ya-ling2,HE Yong-jun2 (1.School of Chemical and Materials Engineering,Southen Yangtze University,Wuxi 214122,China;2.Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China);Synthesis of N,N′-Bis(Dihydroxypropxyl)-2,3,5,6-Tetraiodoterephthalamide[J];Journal of Southern Yangtze University(Natural Science Edition);2007-01
5 ZOU Pei,LUO Shi-neng,LIU Ya-ling,XIE Ming-hao,HE Yong-jun,YANG Zheng(Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China);Determination of related substances in ioversol by HPLC[J];The Chinese Journal of Modern Applied Pharmacy;2005-01
6 ZOU, Pei a,b LIU, Ya-Linga,b LUO, Shi-Nenga XIE, Min-Haoa HE, Yong-Juna SHEN, Yong-Jia*,b (a Jiangsu Institute of Nuclear Medicine, Wuxi 214063) (b Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237);Synthesis of N,N'-Bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-hydroxy-acetamido]-2,4,6-triiodoisophthalamide[J];Chinese Journal of Organic Chemistry;2005-10
7 ZOU Pei,LUO Shi-neng,XIE Min-hao,LIU Ya-ling,HE Yong-jun Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China;Research on the synthesis of ioversol[J];Pharmaceutical and Clinical Research;2009-01
8 ZOU Pei1,2,LUO Shi-neng1,LIU Ya-ling1,XIE Min-hao1,HE Yong-jun1,SHEN Yong-jia2(1 Jiangsu Institute of Nuclear Medicine,WuXi 214063,China;2 Institute of Fine Chemicals,East China University of Science and Technology,Shanghai 200237,China);HPLC determination of ioversol[J];Chinese Journal of New Drugs;2004-S1
9 ZOU Pei~1, LUO Shi-neng~1, WANG Lin-xiang~2, LIU Ya-ling~1, XIE Min-hao~1, HE Yong-jun~1(1 Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China; 2 Centre of Analysis, Southern Yangtze University, Wuxi 214036, China);Determination of residual solvents in ioversol by head space-gas chromatography[J];Chinese New Drugs Journal;2005-02
China Proceedings of conference Full-text Database 1 Hits
1 ;The development of iodinated X-ray contrast agents[A];[C];2004
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