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STUDY ON THE PATHOGENESIS OF OSTEO-TRANSFORMATION IN CHILDREN'S SKELETAL FLUOROSIS

ZHANG Hua, et al. (Department of Preventive Medicine, Guiyang Medical College, Guiyang 550004)  
In order to go further into the influential factors and the pathogenesis of different types of skeletal fluorosis, andprovide scientific basis for working out effective measures to prevent and treat fluorosis, animal model of fluorosis was inducedwith food and high fluoride content coal burning of the endemic area based on the survey of environmental epidemiology before. Inthis experiment, 180 wistar rats were divided into 6 groups, namely. (1) high dose fluoride, (2) high dose fluoride with nutrientsuppliment, (3) low dose fluoride, (4) low dose fluoride with nutrient suppliment, (5) pollution of coal burning, (6) control.The results showed that all rats except those of control group had dental fluorosis. By means of skeletal roentgenoscopy and pathological determinations osteoporosis followed abnormal osteo-transformation was found in rats of group 1. The supplementation ofnutrients is beneficial to reduce skeletal fluorosis. Fluoride absorbed by respiratory tract can also cause skeletal fluorosis, but it wasless serious. The main influential factors which led up to various types of skeletal fluorosis are total fluoride intake, malnutrition(protein and calcium insufficiency) and high intake of alnuminium compounds, etc.
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