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《Modern Preventive Medicine》 2006-05
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A STUDY OF CHRONIC INJURY MODEL INDUCED BY 10% CARBON TETRACHLORIDE.

WANG Yu,CHENG Wei-Bo.ZHANG Yin-zhu,et al.Department of Pathology,West China School of Public health,Sichuan University,Chengdu 610041.  
Objective:To observe pathological changes of liver induced by 10% carbon tetrachloride in rats,and to make an annimal model of it.Methods:Eighty Wistar rats were randomly devided into 2 groups.The samples of liver were taken at 48 hours after poisoning with the hematoxylin-eosin.Masson,Relculin stains and examined under light microscope.Result:The first week,the hepatic cells occurred fatty degeneration and ballooning degeneration;in the sixth week,Necrotic hepatic cells around centric vein were observed;in the eighth week,the liver turned into Hepatic fibrosis.Conclusion:The chronic model in rats induced by 10% CCl_4 should not be use to judge the positive effect of medicine and health food on chronic liver injury.
【CateGory Index】: R363
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